People with autosomal dominant hyper-immunoglobulin E syndrome (HIES) have recurrent bacterial infections of the skin and lungs. Patients with HIES typically also have eczema, distinct facial features, and a tendency to experience bone fractures. The disease has several other names, including Job’s syndrome, STAT3 deficiency, and Buckley syndrome.
HIES is a primary immune deficiency disease (PIDD). For more information on PIDD research and patient care at NIAID, visit the NIAID PIDD site.
For further information about HIES, visit the National Library of Medicine, Genetics Home Reference autosomal dominant hyper-IgE syndrome site.
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