Administrative Supplements for Women’s Health Research in U3 Populations

Funding News Edition: October 05, 2022
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The Office of Research on Women’s Health (ORWH) announced the availability of administrative supplements supporting ongoing research projects through a Notice of Special Interest (NOSI): Research on the Health of Women of Understudied, Underrepresented, and Underreported (U3) Populations (Admin Supp Clinical Trial Optional).

NIAID is participating in the NOSI. Its primary objective is to encourage rigorous experimental designs and implementation of collaborative interdisciplinary research on the complex intersection of women’s health, sex and gender, and social determinants of health to reduce health inequalities among women who are understudied, underrepresented, or underreported in biomedical research.

Scientific Areas of Interest

This NOSI supports preclinical, clinical, behavioral, and translational projects highlighting common sources of disparities in women and girls’ health with a specific emphasis on those that integrate measures beyond the individual level and consider perspectives from multiple disciplines. This includes research projects with multilevel interventions, community-engaged approaches, or one or more NIH-designated health disparities populations.

The proposed research must address at least one objective from strategic goals 1, 2, or 3 of the 2019-2023 Trans-NIH Strategic Plan for Women’s Health Research, Advancing Science for the Health of Women.

Additionally, the COVID-19 pandemic has magnified longstanding challenges and barriers that women and girls face. Supplemental research could address these challenges with respect to gendered work, lower paid positions and economic instability, gender-based violence, and unsafe housing—including the intersection of bias and discrimination based on race, sexual orientation, disability, age, and socioeconomic status.

The NOSI provides extensive example areas for research studies. Within that list, NIAID is most interested in:

  • Examination of systemic factors that influence morbidity, mortality, and healthcare access, entry, and/or retention
    • Studies of health interventions that incorporate constructs and measurement of structural racism and/or discrimination
    • Studies exploring gender-sensitive training for providers to optimize outcomes and reduce gender-based health inequalities
  • Studies investigating risk factors associated with COVID-19 disease prevalence among underserved and underrepresented populations of women (e.g., frontline healthcare workers, women with low socioeconomic status, women who are pregnant and lactating, and women who are homeless or involved in the justice system)
    • Studies exploring caretaking responsibilities and resilience in the context of the COVID-19 pandemic
    • Studies exploring Post-Acute Sequelae of SARS-CoV-2 (PASC) infection (long COVID), or long-term effects of COVID-19 among understudied, underrepresented, underreported populations of women
  • Studies where principles of computational modeling are employed to explore sex and gender differences and health disparities questions relevant to psychopathology, with an emphasis on models with the potential to lead to clinically useful applications/intervention insights for populations of women

How to Apply

Submit applications using the funding opportunity announcement Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin, Supp Clinical Trial Optional). Applications are due on January 31, 2023, by 5 p.m. local time of the applicant organization.

Remember, administrative supplements require that the supported research be within the approved scope of an ongoing award. Before applying, we strongly encourage you to discuss with the program officer assigned to your current grant whether your proposed research is within scope.

Applicants can request only one year of support with budgets limited to $140,000 in direct costs. Additionally, you should include the NOSI’s notice number “NOT-OD-22-208” in the Agency Routing Identifier field (box 4B) of the SF 424 (R&R) Form.

Contact Information

For all inquiries, contact Dr. Damiya Whitaker, in the Office of Research on Women’s Health (ORWH) at 301-451-8206 or

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