Provide Input on Developing 3D Cellular Senescence Maps in Mice

Funding News Edition: April 07, 2021
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Through Request for Information: Challenges and Opportunities in Understanding Cellular Senescence and Senolytics, NIH is collecting community feedback on developing 3D cellular senescence maps in mice to inform the role of cellular senescence in health and disease and the consequences of interventions targeting this process.

Share your comments and ideas for the following:

  1. The mouse strains that offer the greatest opportunity to characterize the heterogeneity versus universality of senescence features
  2. The mouse tissues that should be prioritized
  3. The minimum number of mice needed at each age/sex to generate the maximum confidence level in the study
  4. The ages of mice that should be suitable for
    1. Developing methods tools, or community resources that would be required to define biomarkers of cell senescence in multiple contexts
    2. Characterizing the multiple drivers of cell senescence, both pathological and physiological, across lifespan
    3. Understanding the health consequences of senescent cell accumulation
    4. Characterizing attributes of physiological senescence during normal development and wound healing and their similarities or differences compared to pathological senescence

Email your comments to CS2@nih.gov before the April 30, 2021 deadline. Take care not to include confidential information in your response.

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