Funding News Edition: May 20, 2020 See more articles in this edition
The National Cancer Institute (NCI) will lead NIH efforts to develop, validate, improve, and implement serological testing and associated technologies. Robust serologic testing is key to our understanding population-wide viral pathogenicity, developing and testing SARS-CoV-2 vaccines, and understanding antibody production and immunity.
Through the Request for Information (RFI): Strategy for Research in Coronavirus Serology Testing and Serological Sciences, NCI is soliciting community feedback on two research topics related to serology:
- Research about the relationship between immunity, recent infection, antibody production, and other immunological markers
- The role and value of animal models and in vitro assays for determining the relationship between antibody production and immunity to SARS-CoV-2
- The types and titers of antibodies that are important for immune protection and the mechanism of such protection
- Whether cross-reacting antibodies from prior infection by other coronaviruses confer immunity
- Whether antibodies to coronaviridae can cause immunopathogenesis (e.g., ADE)
- Genetic or other host factors that could predict antibody production and innate or adaptive immunity
- Specific virologic factors that mediate the generation of effective host immunity, especially humoral immunity vs. cell-mediated immunity
- Clinical utilization of serological testing
- Design strategies for use in clinical trials and population-based observational studies that are optimal to address the most critical research questions, including biospecimen sampling/biobanking considerations as well as safety and ethical considerations
- Characteristics and performance standards needed for serological testing, whether for seroprevalence surveys or point-of-care tests
- Approaches to rapidly increase capacity for high-quality serology testing in the United States, by leveraging existing infrastructure, especially for underserved communities
- How to use and interpret serological testing results safely, effectively, and equitably
The RFI invites your comments on research approaches for these topics; innovative strategies to advance research progress; the challenges to progress in these areas; emerging trends, advances, technologies, analytic strategies, and perspectives that NCI should consider; potential approaches to gauge research progress and success; and any related topics you consider relevant.
The deadline to respond is May 26, 2020, at 11:59 p.m. Eastern Time.
Responses are voluntary and may be submitted anonymously. Take care not to share any personally identifiable, proprietary, classified, confidential, or sensitive information.