Foster Research on Health of Bisexual and Bisexual+ People

Funding News Edition: September 07, 2022
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NIAID, alongside other NIH institutes and centers (ICs), seeks research project applications through Notice of Special Interest (NOSI): Research on the Health of Bisexual and Bisexual+ People, with an aim of fostering health research training and career development on the health and wellbeing of people who identify as bisexual or bisexual+. Although there has been an increase in sexual and gender minority (SGM)-focused health research and advances in recent years, there has been fewer projects related to bisexual and bisexual+ (bi/bi+) health in the NIH SGM research portfolio despite bi/bi+ people accounting for the largest proportion of SGM (LGBTQI+) people in the United States as of 2022, according to the February 17, 2022 Gallup article “LGBT Identification in U.S. Ticks Up to 7.1 Percent.”

In September 2019, NIH held a Bisexual Health Research Workshop to better define the health needs and disparities of bi/bi+ people and identified four key areas:

  • Life course perspective–different challenges and knowledge gaps that may exist for bi/bi+ people at each stage and during transition stages.
  • Intersecting populations–bi/bi+ individuals may have multiple intersecting minoritized identities, all of which can have important implications for health and optimal research approaches.
  • Key health inequalities–members of the bi/bi+ community experience unique health-related disparities and may require tailored interventions or prevention-based approaches to help address them, as well as accompanying strategies to overcome implementation barriers.
  • Social determinants of bi/bi+ health–social and structural determinants and drivers play a significant role in many facets of the health of bi/bi+ people.

Research Objectives

The goals of this NOSI are to stimulate research into the biomedical, clinical, behavioral, and social processes that affect bi/bi+ people’s health and welfare, as well as developing appropriate and relevant preventive strategies and delivery methods.

Note the following examples of NIAID's research areas of interest:

  • Understanding prevalence of common infectious diseases, including upper respiratory infections (influenza and SARS-CoV-2), viral hepatitis, HIV, mycobacterial infections, community-acquired pneumonia, and enteric infections, among bi/bi+ individuals and any unique vulnerabilities or pathogenesis for these infections among this group.
  • Research to optimize participation of bi/bi+ people in studies of interventions for infectious diseases and/or organ transplantation, including studies of small molecule therapeutics and biologics, studies to eliminate HIV and hepatitis B virus, and studies to characterize the effectiveness of these interventions in bi/bi+ populations compared to the general population.
  • Research to describe risk of complications from infectious diseases in bi/bi+ individuals and identify unique features in the epidemiology, pathogenesis, and treatment for this group.
  • Development of strategies that target unique barriers to access in prevention, diagnosis, and treatment of acute and chronic infectious diseases of bi/bi+ people.
  • Development of research training for the full spectrum of the research community concerning unique issues and considerations in bi/bi+ health-related research.

Submission Information

Refer to IC-specific FOA listings in the IC-Specific Application and Submission Information section of this NOSI to identify the FOAs through which each IC will accept applications. NIAID is accepting only R01 and R21 applications for this NOSI.

Applicants must follow all instructions in the SF 424 (R&R) Application Guide and the FOA, as well as indicate the notice number (NOT-OD-22-166) in Field 4B on the SF 424 R&R application form and refer to NOT-OD-22-166 in the abstract to assist in identifying applications submitted to this NOSI.

Project period and budget requirements follow the R01 and R21 parent announcements. The next application deadlines are 5 p.m. local time of the applicant organization on October 5, 2022, for R01s and October 12, 2022, for R21s.

Contact Information

Direct any inquiries to Dr. Keith W. Crawford, NIAID’s scientific/research contact at or at 240-669-2816.

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