June 2018 DMID Council-Approved Concepts

Concepts represent early planning stages for program announcements, requests for applications, or solicitations for Council's input. If NIAID publishes an initiative from one of these concepts, we link to it below. To find initiatives, go to Opportunities & Announcements.

NB: Council approval does not guarantee that a concept will become an initiative.

Table of Contents

Collaborative Influenza Vaccine Innovation Centers (CIVIC)

For the published broad agency announcement, see the June 1, 2018 solicitation, 2018 NIAID Omnibus Broad Agency Announcement and the July 3, 2018 Amendment 1, Collaborative Influenza Vaccine Innovation Centers (CIVIC). For the published request for proposals, see the August 31, 2018 solicitation, CIVICs Statistical, Data Management and Coordination Center (SDMCC).

Leadership Group for an Infectious Diseases Clinical Research Consortium

For the published request for applications, see the October 1, 2018 Guide announcement, Leadership Group for an Infectious Diseases Clinical Research Consortium (IDCRC) (UM1 Clinical Trial Required).

Vaccine and Treatment Evaluation Units (VTEUs)

For the published request for applications, see the October 1, 2018 Guide announcement, Vaccine and Treatment Evaluation Units (VTEUs) (UM1 Clinical Trial Required).

Leadership Group for a Clinical Research Network on Antibacterial Resistance

For the published request for applications, see the July 9, 2018 Guide announcement, Leadership Group for a Clinical Research Network on Antibacterial Resistance (UM1, Clinical Trial Required).

Accelerating Malaria Vaccine Discovery

Program Announcement—proposed FY 2020 initiative

Contact: Annie Mo

Objective: To generate new antigens and/or vaccine candidates against malaria suitable for further downstream development and clinical evaluation.

Description: The overall goal of this initiative is to encourage and stimulate early-phase translational research to accelerate the discovery of malaria vaccine candidates, including those targeting three different life cycle stages (i.e., pre-erythrocytic stage, blood stage, and/or sexual stage) of the parasites that cause human malaria, especially Plasmodium falciparum and P. vivax.

The initiative will support identifying, characterizing, credentialing, and validating new protective* antigens or vaccine candidates with appropriate assay systems or animal models, including:

  • Discovering novel protective antigens/peptides through genomics, proteomics, immunomics, or other ‘omics approaches
  • Identifying, characterizing, credentialing, or validating new protective epitopes
  • Discovering new vaccines using novel technology platforms with either new or already known malaria antigens
  • Structure-based vaccine design and testing
  • Credentialing and validating new vaccine candidates with novel assays or animal models

In addition, this initiative will support design, construction, screening, and in vitro or in vivo preclinical testing of attenuated whole organism antimalarial vaccines, especially late liver stage-arresting whole sporozoite vaccines using genetic manipulation of Plasmodium parasites.

*Note: “Protective” refers to appropriate functional characteristics, such as preventing infection, ameliorating disease, interrupting transmission, or prohibiting relapse, when applicable.

Advancing Research Needed To Develop a Universal Influenza Vaccine

For the published program announcements, see the July 18, 2018 Guide announcements:

Control of Sexually Transmitted Infections (STIs) Through a Comprehensive Understanding of the Natural History of Infection

Program Announcement—proposed FY 2020 initiative

Contact: Carolyn Deal

Objective: To encourage research to advance the understanding of natural history of infection for three STIs: gonorrhea, syphilis, and chlamydia.

Description: Under this initiative, investigators may propose studies that will result in new and improved approaches to understanding the natural history of gonorrhea, syphilis, and chlamydial infections. Any area of basic, translational, clinical research, or epidemiological research may be proposed under this program (no clinical trials). Examples of possible research topics include, but are not restricted to studies to better define:

  • Host response to infection
  • Correlates of protection
  • Clinical endpoints of disease
  • Biological and clinical factors that influence clearance rather than persistence of infection

Research To Advance Vaccine Safety

For the published program announcements, see the July 24, 2018 Guide announcements:

Secondary Analysis of Existing Datasets for Advancing Infectious Disease Research

Program Announcement—proposed FY 2020 initiative

Contact: Ishwar Chandramouliswaran

Objective: To support secondary analyses of existing datasets in the NIAID Bioinformatics Research Centers (BRCs) to address scientific questions relevant to infectious diseases.

Description: This initiative will support small-scale projects that use existing datasets in public data repositories generated by NIAID-funded research projects (alone or in combination with other datasets) to address knowledge gaps in basic and clinical infectious diseases. Applications submitted in response to this program announcement must use data deposited in the NIAID Bioinformatics Research Centers but may combine these datasets with data from other sources, either public or private.

Content last reviewed on October 2, 2018