Through its Immune Mechanisms of Protection Against Mycobacterium Tuberculosis Center (IMPAc-TB) program, NIAID aims to gain a comprehensive understanding of the nature, location, and timing of protective immune responses required to prevent initial Mycobacterium tuberculosis (Mtb) infection, latent infection development, and transition to active TB disease.
The objectives of this comprehensive program are to
- Identify the key immune responses needed for protection against Mtb
- Identify immunologic targets that can be used to improve TB vaccine strategies
- Determine the impact of HIV/SIV and Nontuberculous Mycobacteria infections on relevant immune responses to Mtb infection or TB vaccines
- Improve the predictive value of animal models
- Identify how bacterial immune evasion mechanisms subvert immune responses to Mtb
If you want to be part of this program, consider a new broad agency announcement (BAA) that seeks to establish integrated multidisciplinary teams of highly collaborative investigators from within and outside of the TB field.
As an IMPAc-TB team, investigators will be responsible for activities such as
- Planning and conducting iterative, in-depth immunologic analyses of tissue-specific and systemic responses against Mtb/TB in
- Small animals (mice, guinea pigs, etc.)
- Nonhuman primates (NHPs)
- Developing standard operating procedures and assay harmonization that the Center’s members will implement
- Testing novel, promising vaccine candidates for in-depth immunologic analyses
- Make both positive and negative results and data available to the broader research community to further advance the field
Since this is a BAA, investigators must develop and propose a Statement of Work (SOW), including the specific technical requirements and performance specifications. You must present separate detailed technical and business proposals designed to meet the technical objectives outlined in the BAA.
Read the BAA attachments carefully, as they provide more details on program scope and instructions for proposal development.
Award and Other Information
NIAID anticipates funding up to $19.5 million (direct and indirect costs combined) annually for all awards, depending upon availability of funds and contract progress, with an initial, non-severable base work anticipated to last 12 to 18 months depending on an offeror’s technical approach and proposed milestones.
We also anticipate awarding one to three contracts with performance beginning on or about August 1, 2019. The maximum period of performance for this solicitation is seven years.
Submit your proposal through the electronic Contract Proposal Submission (eCPS) website on or before 3:00 p.m. local time on August 15, 2018.