Funding Available for Research on Mycobacterial-Induced Immunity

Funding News Edition: July 18, 2019
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Take note if your research involves tuberculosis (TB): NIAID reissued a funding opportunity announcement titled Mechanisms of Mycobacterial-Induced Immunity in HIV-Infected and/or Uninfected Individuals To Inform Innovative Tuberculosis Vaccine Design (R01, Clinical Trial Not Allowed).

Scope of Research

This program announcement with special receipt, referral, and/or review considerations (PAR) will support innovative studies to identify and understand protective immune responses against Mycobacterium tuberculosis (Mtb) infection or progression to active TB disease.

Examples of potential research areas of interest include, but are not limited to:

  • Analyzing innate immune pathways and mechanisms in response to Mtb infection and/or TB progression, including trained immunity and the effect on downstream activation of adaptive immune responses
  • Identifying processes associated with mobilization/homing and maintenance of protective immune cells in the lung
  • Investigating the timing/nature of immune responses leading to protection against disseminated TB in children to determine whether activity of Bacillus Calmette-Guérin can be modified to protect adults against Mtb infection or disease
  • Developing novel functional assays to monitor protective immune responses in humans

Applications will not be reviewed if they propose:

  • Projects focused primarily on reagent or animal model development or that address tuberculosis-associated immune reconstitution syndrome (TB-IRIS)
  • Projects focused solely on mechanisms of TB pathogenesis that do not include immune parameter analysis—NIAID will assess responsiveness at the time applications are submitted if there are any concerns
  • Clinical trials

Administrative Notes

The first of three due dates is January 14, 2020, by 5 p.m. local time of the applicant institution. The maximum funding period is five years. Application budgets are not limited but must reflect the actual needs of the proposed project.

If you have any questions, refer to Section VII. Agency Contacts, which lists by division program officers who can help: Drs. Cesar Boggiano (DAIDS), Katrin Eichelberg (DMID), and Nancy Vázquez-Maldonado (DAIT).

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