Concepts represent early planning stages for program announcements, requests for applications, or solicitations for Council's input. If NIAID publishes an initiative from one of these concepts, we link to it below. To find initiatives, go to Opportunities & Announcements .
NB: Council approval does not guarantee that a concept will become an initiative.
Table of Contents
Genomic Centers for Infectious Diseases
For the published request for applications, see the March 15, 2018 Guide announcement, Genomic Centers for Infectious Diseases (U19 Clinical Trial Not Allowed).
Bioinformatics Resource Centers for Infectious Diseases
Request for Proposals—proposed FY 2019 initiative
Contact: Stanley Knight
Objective: To provide data-driven and computational infrastructures and data-sharing platforms to support large-scale, system-level data integration and modeling, and enable predictive biology for pathogens and host-pathogen interactions for discovery research, clinical investigation, and therapeutic development for infectious diseases.
Description: The Bioinformatics Resource Centers (BRCs) will continue to provide established infrastructures as well as scientific and technical expertise to enhance, expand, and make accessible bioinformatics resources and services. Resources include data standardization and collection, software tools and algorithms, analytical pipelines and services, and databases and infrastructures that use state-of-the-art technologies to enable data organization, integration, mining, analysis, sharing, and dissemination. These resources will be made accessible to the infectious diseases community through web interfaces and web services.
Specifically, the BRCs will provide:
- Infrastructures for integrating, computing, accessing, and sharing data for basic, translational, and clinical research studying human pathogens and related organisms, invertebrate vectors of human pathogens, and host-pathogen interactions.
- Bioinformatics tools and services for data mining, visualization, and analysis, including computational approaches for in silico experimentation, advanced methods for predicting phenotypes such as antimicrobial resistance, emergence and transmission of pathogens, and epidemiology modeling, as well as user workspaces with capability of integrative data and workflow management.
- Application of tools in clinical settings to support decision-making for diagnosis and development of therapeutics.
- Interactive access, visualization, and retrieval of data, tools, and other resources within each BRC and across BRCs through web interfaces and web services.
- Platforms for next-generation systems biology investigations to support systems level predictive modeling and knowledge.
- Outreach activities and training opportunities to facilitate collaboration, expand the user-base, and increase utility of the resources and services provided.
Ultimately the BRCs are responsible for understanding and collecting the evolving bioinformatics needs of infectious diseases researchers and of the many pathogen research communities supported by DMID. The bioinformatics infrastructures provided shall be flexible and scalable, and have the capacity to efficiently and rapidly respond to needs as they arise, such as emerging and re-emerging outbreaks.