September 2020 DAIT Council-Approved Concepts

Concepts represent early planning stages for program announcements, requests for applications, notices of special interest, or solicitations for Council's input. If NIAID publishes an initiative from one of these concepts, we link to it below. To find initiatives, go to Opportunities & Announcements.

NB: Council approval does not guarantee that a concept will become an initiative.

Table of Contents

Fiscal Year (FY) 2022 Concepts

FY 2023 Concept

Human Immunology Project Consortium (HIPC)

For the published request for applications, see the February 8, 2021 Guide announcement, Human Immunology Project Consortium (HIPC) (U19 Clinical Trial Optional).

Human Immunology Project Consortium (HIPC) – Coordinating Center

For the published request for applications, see the February 8, 2021 Guide announcement, Human Immunology Project Consortium (HIPC) Coordinating Center (U01 Clinical Trial Not Allowed).

The Immunology Database and Analysis Portal (ImmPort)

Request for Proposals—proposed FY 2022 initiative

Contact: Emily Bannister

Objective:

  1. To support the maintenance and improvement of the ImmPort data repository, which hosts data primarily from a select set of NIAID’s research studies and shares the hosted data with the research community.
  2. To transform the shared data into a user-friendly resource to enable reuse of the data to gain new insights and findings to advance immunology research.

Description: This renewal will continue to support the following provisions to the research community:

  • Continue to improve ImmPort as a centralized immunology data repository with templates, user manuals, and tools for researchers to manage data submission and data sharing
  • User-friendly web interfaces and tools for query, download, integration, and analyses of shared data
  • Bioinformatics support for data submission to ImmPort from DAIT-funded research programs
  • Implementation of data and metadata standards and data quality control procedures to facilitate data integration and data reuse
  • Training, tutorials, and other outreach/educational endeavors to promote research data sharing
  • Ensure flexibility to adapt to new research community’s needs for data sharing

Nonhuman Primate Transplantation Tolerance Cooperative Study Group (NHPCSG)

Request for Applications—proposed FY 2023 initiative

Contact: Julia Shaw

Objective: The goals of the NHPCSG, a multi-institution consortium, are to identify and develop novel therapeutic regimens for donor-specific tolerance induction, refine existing regimens, evaluate preclinical efficacy of candidate regimens, and elucidate the underlying mechanisms responsible for the induction, maintenance, and/or loss of tolerance in NHP organ and islet transplant models.

Description: This initiative will support research projects that use NHP for allogeneic studies of islet, kidney, heart, liver, intestine, and lung transplantation. This reflects an expansion of scope in order to include newly established NHP models of liver and intestinal transplantation. The studies will address the overarching goals of the NHPCSG, including: 1) identifying and developing novel immune tolerance induction regimens and/or refining of existing regimens; 2) evaluating safety and efficacy of candidate regimens; 3) developing and validating biomarkers or novel methods for assessing induction, maintenance, and/or loss of immune tolerance or prediction of graft rejection; and 4) elucidating mechanisms responsible for tolerance induction, maintenance, and/or loss. This initiative will also include a discretionary fund to capitalize on emerging opportunities through the support of short-term pilot or feasibility projects.

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