The World Health Organization recently declared antibacterial resistance to be one of the top ten threats to global health. The NIAID-funded Antibacterial Resistance Leadership Group (ARLG) has established projects, networks, and partnerships that will assist scientists as they fight resistant bacteria.
A weapon made from spider toxin destroys blood-sucking enemies from the inside and helps save people from disease and death. It sounds like the plot of a superhero movie, but it’s actually a new way to combat malaria. NIAID-funded researchers who developed a genetically modified mosquito-killing fungus and tested it in the West African nation of Burkina Faso have shown that it even works against mosquitoes that have become resistant to chemical insecticides.
Around the world, bacteria are now developing resistance to many common antibiotics, which threatens their effectiveness and puts millions of lives at risk. NIAID Now spoke to Dr. Keith Kaye, the Principal Investigator of the OVERCOME trial, which focuses on the best ways to use antibiotics in order to increase their lifespans as useful treatment options.
Malaria is caused by a tiny parasite that infects human livers and red blood cells, and which is transmitted from person to person by a female mosquito. NIAID-funded researchers investigated how the parasite takes nutrients to complete completes critical life stages inside a mosquito without harming the mosquito's ability to lay eggs.
See new infographics from the Centers of Excellences for Influenza Research and Surveillance (CEIRS) network. NIAID established the CEIRS network in 2007 to continue and expand the fight against emerging and developing strains of flu. CEIRS now helps provide information and public health tools to control the threats of both epidemic and pandemic influenza.
Tickborne diseases are a growing problem in the United States. In response to recommendations from the Tick-borne Disease Working Group, the NIH is developing a strategic plan to advance tickborne disease research and development, and is seeking comments and suggestions from stakeholders throughout the scientific research, advocacy, and clinical practice communities, and the general public.
Even after standard antibiotic treatments, tuberculosis patients can relapse if not all the bacteria are killed. By re-examining patients’ sputum, or thick saliva, collected from other studies, NIAID-funded researchers found a way to determine whether patients are likely to relapse following standard treatment.
An advanced electron microscopy technique has given scientists a clearer picture of a molecule used by insects to smell their way around.
NIH Director Francis S. Collins, M.D., Ph.D., keeps the public posted on fascinating NIH-supported research in biweekly posts on the NIH Director's Blog. The blog features the work of scientists from many of NIH's institutes and centers, as well as NIH grantees and collaborators, and NIAID is no exception.
August 20 is World Mosquito Day. NIAID is part of the fight against these death-dealing insects.
NIAID supported the development of a new drug to treat smallpox, the first to be approved specifically to treat the viral disease.
PATRIC is one of six NIAID-funded Bioinformatics Resource Centers (BRCs) for Infectious Diseases and focuses on bacterial species. The BRCs compile large datasets in a standardized way, allowing scientists to perform analyses more efficiently. This can include assessing the function of specific genes, identifying markers for diagnosing a particular bacterial infection, or discovering new bacterial resistance mechanisms.
A clinical trial comparing three chemotherapy regimens in combination with antiretroviral treatment for treatment of advanced AIDS-Kaposi’s sarcoma patients in Africa and South America has ended early.
The collaboration made possible the rapid and robust sharing of Zika materials such as Zika isolates and serum samples.
A new video from NIAID explores a possible new way to fight bacteria as they become increasingly resistant to antibiotics.
Each year, NIAID-funded scientists visit the beaches of Delaware Bay to test shorebirds for avian flu viruses. A video from NIAID Now profiles their work.
In a new study in Science Translational Medicine, NIAID-funded researchers probe the tuberculosis bacterium’s cell membrane construction processes—and find a weakness that future TB drugs could exploit to halt the bacteria’s growth.
NIAID is conducting and supporting research, including two clinical trials, on the potentially deadly disease Valley fever, or coccidioidomycosis. People can get Valley fever by inhaling a soil-residing fungus endemic to parts of the southwestern United States.
In 2016, an estimated 216 million people developed malaria. In a new video from NIAID, Dr. Lee Hall, chief of the Parasitology and International Programs Branch in NIAID’s Division of Microbiology and Infectious Diseases, discusses the urgent need for malaria research, and how NIAID is supporting and conducting investigation into new diagnostics, drugs, vaccines and more.
Dr. Erica Ollmann Saphire, speaker at the 2017 Joseph J. Kinyoun Memorial Lecture, has spearheaded a global effort to find antibodies that work against small-genomed viruses like Ebola and Lassa.
Bacterial infections that resist antibiotics are a major problem in the United States. In 2015, the U.S. government launched the National Action Plan for Combating Antibiotic-Resistant Bacteria. Guided by the plan, NIAID and other NIH components work with government, academic, and industry partners on a wide range of projects aimed at understanding and controlling antibiotic resistance. To mark this year’s Antibiotic Awareness Week, November 13-19, we highlight a few of these efforts.
NIAID-funded scientists have found that a new Zika vaccine candidate can protect pregnant mice and their fetuses, as well as male mice and monkeys, with just one dose.
Findings from a pair of NIAID-funded studies in zebrafish shed light on how nerve damage is initiated in leprosy and suggest a potential target for the development of strategies to prevent tuberculosis and other mycobacterial diseases.
It’s easy for people to overlook the importance of fast, reliable diagnostic tests in scientific research. Most often, ill patients focus on what treatment is available for them to recover. But without a timely and accurate diagnosis, physicians won’t know the most optimal treatment to provide.
In recent years, multidrug-resistant (MDR) and extensively-drug-resistant (XDR) tuberculosis (TB) has become increasingly common—and difficult to treat. A new study funded by NIAID reveals that by unravelling the TB bacteria’s DNA and testing it for certain mutations, researchers were able to estimate to what extent the bacteria are resistant to fluoroquinolones, a class of powerful antibiotics typically used to treat TB.
Each May, NIAID-funded researchers descend on the beaches of Delaware Bay in New Jersey to screen migratory shorebirds for the flu. Through this work, they are learning more about how influenza viruses spread and evolve.
Read the report and recommendations on a possible Zika virus human challenge study.
View the meeting summary from the joint WHO and NIAID/NIH conference on Zika Virus vaccine development.