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Antimicrobial Drug Resistance

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NIAID-led Work Identifies Bacteria Signaling for Nerve Repair in Mice

January 18, 2023

A team of NIAID-led researchers has identified a mechanism in mice in which the immune system and commensal bacteria help repair damaged sensory neurons within the skin. They hope their findings could lead to therapies that stimulate recovery in people following skin injury and limit damage from chemotherapy and chronic diseases.

This confocal microscope image shows a ring of nerve regeneration occurring in mice (bottom right). Scientists exposed the mice to commensal bacteria (Staphylococcus aureus), then a month later the mice sustained an ear injury (biopsy). Ten days later the scientists took the image to document the nerve fiber recovery progress associated with immune cell responses (gold staining).

Candida auris—a mysterious and tenacious enemy

September 23, 2022

Candida auris, is an emerging healthcare-associated infection of growing public health concern. NIAID supports several researchers who are asking fundamental questions about the biology of C. auris. Today’s NIAID Now post features insights from NIAID-funded researchers, Jeniel Nett, M.D., Ph.D., associate professor of medicine and medical microbiology and immunology at University of Wisconsin-Madison, and Christina Cuomo, Ph.D., associate director of the Genomic Center of Infectious Diseases at the Broad Institute of Massachusetts Institute of Technology and Harvard University.

A medical illustration of Candida auris fungal organisms. They appear as blue spheres.

NIAID Scientists Identify New, Rapid Response to Bacterial Skin Infection

December 10, 2021

A new study in mice from NIAID scientists now shows that toxins from Staphylococcus aureus alarm the immune system hours earlier than previously known.

Scanning electromicrograph of Staphylococcus aureus bacteria.

NIAID Observes World Antimicrobial Awareness Week 2021

November 24, 2021

Antimicrobials such as antibiotics, antivirals, and antifungal drugs are crucial tools in the fight against disease-causing microbes. However, resistance of microbes to these life-saving medicines is a growing global public health dilemma. In fact, the Centers for Disease Control and Prevention (CDC) reports that more than 2.8 million infections and over 35,000 deaths are caused by antibiotic-resistant pathogens in the US annually.

Oral Probiotic Bacillus Prevents Enterococcal Sepsis in Mouse Study

November 24, 2021

A new study from NIAID's Intramural research program provides an update on research into using a probiotic to treat bacterial gut infections.

Childhood Pneumonia Study Shows Short-Course Antibiotics Superior to Standard of Care

October 23, 2020

A NIAID-sponsored study has shown that short-course antibiotic treatment is superior to standard treatment of community-acquired pneumonia in children.