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Autoimmune Diseases
9 Results

August 2021

NIH Launches Study of Extra COVID-19 Vaccine Dose in People with Autoimmune Disease

August 27, 2021

The National Institutes of Health has begun a clinical trial to assess the antibody response to an extra dose of an authorized or approved COVID-19 vaccine in people with autoimmune disease who did not respond to an original COVID-19 vaccine regimen. The trial also will investigate whether pausing immunosuppressive therapy for autoimmune disease improves the antibody response to an extra dose of a COVID-19 vaccine in this population.

Image of cell infected with SARS-CoV-2

May 2021

Gene Therapy Restores Immune Function in Children with Rare Immunodeficiency

May 11, 2021

An investigational gene therapy can safely restore the immune systems of infants and children who have a rare, life-threatening inherited immunodeficiency disorder, according to research supported in part by the National Institutes of Health.

A DNA double helix rests on a print-out illustration of the DNA letters A, T, C and G.

January 2020

New Multiple Sclerosis Treatment Trial Compares Stem Cell Transplantation to Best Available Drugs

January 07, 2020

A clinical trial has begun testing an experimental stem cell treatment against the best available biologic therapies for severe forms of relapsing multiple sclerosis (MS). The trial, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, will compare the safety, efficacy and cost-effectiveness of the two therapeutic approaches. 

Human T cell

September 2018

NIAID and Children’s National Partner to Advance Pediatric Clinical Research

September 17, 2018

NIAID and the Children’s National Health System partner to advance pediatric clinical research.

April 2018

Epstein-Barr Virus Protein Can “Switch On” Risk Genes for Autoimmune Diseases

April 16, 2018

Infection with Epstein-Barr virus (EBV), the cause of infectious mononucleosis, has been associated with subsequent development of systemic lupus erythematosus and other chronic autoimmune illnesses, but the mechanisms behind this association have been unclear. Now, a novel computational method shows that a viral protein found in EBV-infected human cells may activate genes associated with increased risk for autoimmunity. Scientists supported by the National Institute of Allergy and Infectious Diseases report their findings today in Nature Genetics.

March 2018

Islet Transplantation Improves Quality of Life for People with Hard-to-Control Type 1 Diabetes

March 21, 2018

Quality of life for people with type 1 diabetes who had frequent severe hypoglycemia—a potentially fatal low blood glucose (blood sugar) level—improved consistently and dramatically following transplantation of insulin-producing pancreatic islets, according to findings published online March 21 in Diabetes Care.

January 2018

Stem Cell Transplant for Severe Scleroderma Improves Survival, Quality of Life

January 03, 2018

New clinical trial findings show that a therapeutic regimen involving transplantation of a person’s own blood-forming stem cells can improve survival and quality of life for people with severe scleroderma, a life-threatening autoimmune disease. The regimen, known as myeloablative autologous hematopoietic stem cell transplant (HSCT), includes chemotherapy and total body radiation to destroy the bone marrow followed by transplantation of the person’s own blood-forming stem cells to reconstitute the marrow and immune system.

February 2017

Stem Cell Transplants May Induce Long-Term Remission of Multiple Sclerosis

February 01, 2017

New clinical trial results provide evidence that high-dose immunosuppressive therapy followed by transplantation of a person's own blood-forming stem cells can induce sustained remission of relapsing-remitting multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system. 

April 2016

Islet Transplantation Restores Blood Sugar Awareness and Control in Type 1 Diabetes

April 18, 2016

New clinical trial results show that transplantation of pancreatic islets—cell clusters that contain insulin-producing cells—prevents severe, potentially life-threatening drops in blood sugar in people with type 1 diabetes.

A doctor speaks with her patient.