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Sexually Transmitted Diseases
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May 2019

Photo of Neisseria gonorrhoeae bacteria

NIH Awards Will Advance Development of Vaccines for Sexually Transmitted Infections

May 09, 2019

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, today announced awards to establish four Cooperative Research Centers (CRCs) focused on developing vaccines to prevent sexually transmitted infections (STIs). The grants, totaling $41.6 million over five years, will support collaborative, multidisciplinary research on the bacteria that cause syphilis, gonorrhea and chlamydia. At the end of the program, each center is expected to identify at least one candidate vaccine ready for testing in clinical trials.

November 2018

Image of Neisseria gonorrhoeae bacteria, which causes gonorrhea

Novel Antibiotic Shows Promise in Treatment of Uncomplicated Gonorrhea

November 07, 2018

An investigational oral antibiotic called zoliflodacin was well-tolerated and successfully cured most cases of uncomplicated gonorrhea when tested in a Phase 2 multicenter clinical trial, according to findings published today in the New England Journal of Medicine. The National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health, sponsored the clinical study. 

August 2017

Image of  herpes simplex virus infection being suppressed in cells

NIH Herpesvirus Study in Mice Leads to Discovery of Potential Broad-Spectrum Antiviral

August 15, 2017

After herpesviruses infect a cell, their genomes are assembled into specialized protein structures called nucleosomes. Many cellular enzyme complexes can modulate these structures to either promote or inhibit the progression of infection. Scientists studying how one of these complexes (EZH2/1) regulated herpes simplex virus (HSV) infection unexpectedly found that inhibiting EZH2/1 suppressed viral infection.

June 2017

NIH Study: Glutamine Suppresses Herpes in Mice and Guinea Pigs

June 16, 2017

Glutamine supplements can suppress reactivation of herpes simplex virus (HSV) in mice and guinea pigs, according to findings recently published in the Journal of Clinical Investigation. The research was conducted by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), and at the U.S. Food and Drug Administration (FDA).

April 2017

The left image shows typical HSV reactivation from latency in neurons. On the right, viral reactivation is stimulated by compounds that activate the HCF-1 binding partners.

NIH Scientists Advance Understanding of Herpesvirus Infection

April 12, 2017

Herpes simplex virus (HSV) infections last a lifetime. Once a person has been infected, the virus can remain dormant (latent) for years before periodically reactivating to cause recurrent disease. This poorly understood cycle has frustrated scientists for years. Now, National Institutes of Health (NIH) scientists have identified a set of protein complexes that are recruited to viral genes and stimulate both initial infection and reactivation from latency.  Environmental stresses known to regulate these proteins also induce reactivation.

November 2016

NIAID-Supported Study Examines Vulnerability of Gonorrhea to Older Antibiotic Drug

November 17, 2016

A new clinical research study seeks to determine whether a rapid molecular diagnostic test can reliably identify gonorrhea infections that may be successfully treated with a single dose of an older antibiotic, ciprofloxacin. The study will enroll up to 381 men and women diagnosed with untreated Neisseria gonorrhoeae. It is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.