5 Results
The Antiviral Tecovirimat is Safe but Did Not Improve Clade I Mpox Resolution in Democratic Republic of the Congo
August 15, 2024
The antiviral drug tecovirimat did not reduce the duration of mpox lesions among children and adults with clade I mpox in the Democratic Republic of the Congo (DRC), based on an initial analysis of data from a randomized, placebo-controlled trial. However, the study’s 1.7% overall mortality among enrollees, regardless of whether they received the drug or not, was much lower than the mpox mortality of 3.6% or higher reported among all cases in the DRC. This shows that better outcomes among people with mpox can be achieved when they are hospitalized and provided high-quality supportive care.
NIH Study Finds Tecovirimat Was Safe but Did Not Improve Mpox Resolution or Pain
December 10, 2024
Tecovirimat was safe but did not reduce the time to lesion resolution or reduce pain among adults with mild to moderate clade II mpox and a low risk of severe disease in an international study.
Mpox Vaccine Is Safe and Generates a Robust Antibody Response in Adolescents
October 16, 2024
A clinical trial of an mpox vaccine in adolescents found it was safe and generated an antibody response equivalent to that seen in adults. Results were presented at IDWeek2024.
NIH Releases Mpox Research Agenda
September 17, 2024
The NIAID mpox research agenda focuses on four key objectives: increasing knowledge about the biology of all clades—also known as strains—of the virus that causes mpox, including how the virus is transmitted and how people’s immune systems respond to it; evaluating dosing regimens of current vaccines to stretch the vaccine supply and developing novel vaccine concepts; advancing existing and novel treatments, including antivirals and monoclonal antibodies; and supporting strategies for detecting the virus to facilitate clinical care and epidemiological surveillance.
Lower Dose of Mpox Vaccine Is Safe and Generates Six-Week Antibody Response Equivalent to Standard Regimen
April 27, 2024
A dose-sparing intradermal mpox vaccination regimen was safe and generated an antibody response equivalent to that induced by the standard regimen at six weeks (two weeks after the second dose), according to findings presented today at the European Society of Clinical Microbiology and Infectious Diseases Global Congress in Barcelona. The results suggest that antibody responses contributed to the effectiveness of dose-sparing mpox vaccine regimens used during the 2022 U.S. outbreak.
