The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is expanding its Tuberculosis Research Units (TBRU) program in an effort to drive innovation in tuberculosis (TB) research. NIAID is awarding up to $15.2 million in fiscal year 2015 and as much as $105.3 million over seven years to fund four institutions that will act as a collaborative TBRU network.
A critical component of NIAID's tuberculosis research, the TBRU program was established in 1994 with the aim of integrating basic and clinical research to study TB in countries where the disease is endemic. For the past 20 years, one TBRU operated under a contract with Case Western Reserve University with study sites in Uganda, Brazil, the Philippines and South Africa and active research collaborations worldwide. This TBRU has helped to identify biomarkers that define the various stages of infection and disease, contributed to best practices for TB clinical trials, and examined factors to help understand why some people infected with the disease-causing Mycobacterium tuberculosis do not develop TB.
Although the number of individuals becoming sick or dying from TB worldwide has slowly declined in recent years, the global burden of the disease remains substantial. About one-third of the world's population carries latent TB bacteria, according to the World Health Organization. In 2013, an estimated 9 million people became ill with TB and 1.5 million died from the disease. More than 500,000 children developed TB in 2013 and 80,000 died from the infection, according to WHO.
Project name: Biomarkers and Mechanisms of Paucibacillary and Latent Tuberculosis
Principal investigator: Jerrold Ellner, M.D.
Co-principal investigators: David Alland, M.D., and Padmini Salgame, Ph.D., Rutgers University
Project name: Metabolic Factors that Control the Spectrum of Human Tuberculosis
Principal investigator: D. Branch Moody, M.D.
Co-principal investigator: Megan Murray, M.D., Harvard School of Public Health
Project name: Role of Antigen-Specific T Cell Responses in the Control of TB
Principal investigator: Henry Blumberg, M.D.
Co-principal investigator: Joel Ernst, M.D., New York University
Project name: Tri-Institutional TB Research Unit: Persistence and Latency
Principal investigator: Carl Nathan, M.D.
Co-principle investigator: Michael Glickman, M.D., Sloan Kettering Institute for Cancer Research