Oral immunotherapy for peanut allergy induces early, distinct changes in immune T-cell populations that potentially may help researchers determine which people will respond well to the therapy and which immune mechanisms are involved in the response, a new study suggests. The work was funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and conducted by scientists at Stanford University.
JF Ryan et al. Successful immunotherapy induces novel allergen-specific CD4+ T cell subsets. Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.1520180113 (2016).
Wendy Davidson, Ph.D., a program officer in the Allergy, Asthma and Airway Biology Branch in NIAID's Division of Allergy, Immunology and Transplantation, is available to discuss the findings.