New research has illuminated the movement and complete structure of the spikes on HIV that the virus uses to bind to the cells it infects. This research, led by scientists at the National Institutes of Health, Weill Cornell Medical College and Yale University School of Medicine, could help advance efforts to develop HIV vaccines and treatments.
Munro et al. Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions. Science DOI: 10.1126/science.1254426 (2014).
Pancera et al. Structure and immune recognition of trimeric prefusion HIV-1 Env. Nature DOI: 10.1038/nature13808 (2014).
Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID); Peter D. Kwong, Ph.D., chief of the Structural Biology Section and Structural Bioinformatics Core at the NIAID Vaccine Research Center; and Jason Gorman, Ph.D., research fellow in the Structural Biology Section at the NIAID Vaccine Research Center, are available for comment.
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