A phase 2 open-label study to evaluate the efficacy and safety of ruxolitinib on hair regrowth in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)- associated alopecia areata

The purpose of this study is to see if a study drug (ruxolitinib) can help hair regrowth in people with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)-associated alopecia areata (AA) and if it can improve other symptoms caused by the immune system s attack to the body.

Contact Information

Office: Building 10, CRC Room 11C120, Bethesda, MD 20892
Phone: 301-443-8341
Email: repairestudyteam@mail.nih.gov
Hours: 7:00 am-3:30pm EST Mon-Fri

Notice of Special Interest (NOSI)—Advancing Research Needed to Develop a Coccidioidomycosis (Valley fever) Vaccine

The purpose of this Notice of Special Interest (NOSI) is to highlight NIAIDs interest in supporting research in the areas outlined in the NIAID Strategic Plan For Research To Develop A Valley Fever Vaccine. The proposed research should have clear relevance to the strategic priorities defined in the strategic plan, which encompasses three major research areas: 1) address gaps in Coccidioides basic research to support the development of a vaccine; 2) develop tools and resources to support vaccine development; 3) develop and advance vaccines to prevent coccidioidomycosis.

January 2023 Trans-Divisional Council-Approved Concepts

Concepts represent early planning stages for program announcements, requests for applications, notices of special interest, or solicitations for Council's input. If NIAID publishes an initiative from one of these concepts, we link to it below. To find initiatives, go to Opportunities & Announcements.

Note: Council approval does not guarantee that a concept will become an initiative.

Table of Contents

Fiscal Year (FY) 2024 Concepts

January 2023 DMID Council-Approved Concepts

Concepts represent early planning stages for program announcements, requests for applications, notices of special interest, or solicitations for Council's input. If NIAID publishes an initiative from one of these concepts, we link to it below. To find initiatives, go to Opportunities & Announcements.

Note: Council approval does not guarantee that a concept will become an initiative.

Table of Contents

Fiscal Year (FY) 2024 Concepts

January 2023 DAIT Council-Approved Concepts

Concepts represent early planning stages for program announcements, requests for applications, notices of special interest, or solicitations for Council's input. If NIAID publishes an initiative from one of these concepts, we link to it below. To find initiatives, go to Opportunities & Announcements.

Note: Council approval does not guarantee that a concept will become an initiative.

Table of Contents

Fiscal Year (FY) 2024 Concepts

January 2023 DAIDS Council-Approved Concepts

Concepts represent early planning stages for program announcements, requests for applications, notices of special interest, or solicitations for Council's input. If NIAID publishes an initiative from one of these concepts, we link to it below. To find initiatives, go to Opportunities & Announcements.

Note: Council approval does not guarantee that a concept will become an initiative.

Table of Contents

Fiscal Year 2024 Small Business Innovation Research (SBIR) Contract Solicitation Topics

APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)

The APOLLO study is being done in an attempt to improve outcomes after kidney transplantation and to improve the safety of living kidney donation based upon variation in the apolipoprotein L1 gene (APOL1).

Vaccines Information for Researchers

Photo of Zika virus researcher at the NIAID Vaccine Research Center loading samples into a microcentrifuge.

A Zika virus researcher at the NIAID Vaccine Research Center loads samples into a microcentrifuge.

Credit: NIAID

Despite many accomplishments in vaccine research over the years, much remains to be done. NIAID-supported investigators in the United States and other countries and in NIAID laboratories in Bethesda, Maryland, and Hamilton, Montana, are working to reduce the burden of illness by helping to develop vaccines against diseases old and new.

NIAID has three broad goals in vaccine research:

  1. Identify new vaccine candidates to prevent diseases for which no vaccines currently exist.
  2. Improve the safety and efficacy of existing vaccines.
  3. Design novel vaccine approaches, such as new delivery systems and adjuvants.

To achieve these goals, NIAID conducts and supports basic and applied research in fields such as immunology, microbiology, and disease pathology.

View NIAID’s Reports and Strategic Plans relevant to vaccine research and development.

COVID-19 Vaccines

Next Generation COVID-19 Vaccines

NIAID plans to leverage existing infrastructure and network sites to implement a structured program evaluating up to 10 next generation COVID-19 vaccines in Phase 1 and Phase 2 clinical trials.

cartoon of single helix mRNA and a circular graphic of Bubbles of fat”, a vile of covid-19 vaccine, a person wearing a mask
Credit
NIAID

COVID-19 mRNA Vaccines

NIAID has participated in mRNA vaccine research and development. This infographic shows the mRNA vaccine components, development timeline, and an overview of the numbers of doses administered, lives saved, hospitalizations prevented and costs averted.

Research Support

Connect With Other Researchers

Researchers at NIAID

Many NIAID labs are engaged in adjuvant research. Investigators from the Laboratory of Malaria Immunology and Vaccinology, Laboratory of Parasitic Diseases, and Laboratory of Systems Biology are collaborating on a special program in vaccine adjuvants. The scientists are evaluating a diverse panel of candidate adjuvants and antigens in mouse and monkey models and in people. In addition, several labs are conducting and participating in adjuvant studies.

Vaccine Adjuvants

Vaccine Adjuvant Research Program

NIAID plays a leading role in the discovery, development, and characterization of new vaccine adjuvants that may be used to: improve the efficacy of current vaccines; design new or improved vaccines for existing and emerging infectious diseases; and develop vaccines to treat allergies, autoimmune diseases, and cancer.

Read about the Vaccine Adjuvant Research Programs

Adjuvant Resources for Researchers

View a list of vaccine adjuvant resources for researchers

Resources for Researchers

NIAID offers many resources to support your research. You may request services if you are an investigator in academia, a not-for-profit organization, industry, or government in the United States or worldwide. You need not be a grantee of NIAID or another National Institutes of Health Institute or Center. Each resource outlines eligibility information.

Read a full list of vaccine resources for researchers

Funding Opportunities

NIAID is funding research on an abundance of vaccine-related research.

Read a full list of vaccine funding opportunities

Programs & Networks

NIAID participates in or funds many different consortia, clinical trial programs, networks, and research collaborations that help to move science forward.

Read about vaccine programs and networks funded by NIAID.

Neglected Tropical Diseases Information for Researchers

NIAID has a long-standing program of research devoted to better understanding, treating, and preventing neglected tropical diseases (NTDs). NIAID conducts its own basic and clinical studies and supports those of researchers based in the United States and in countries where NTDs are widespread.

Through the information offered here, researchers can learn about the science being conducted at NIAID and by NIAID-funded researchers. Researchers seeking funding can access opportunities to further their own research, while NIAID and NIH grantees can find out about available resources outside of specific funding opportunities. Recent publications, active networks, and ways to connect with other researchers are also available.

Programs & Networks

NIAID partners with leaders in the field of neglected tropical diseases research to better understand the diseases and move forward toward better prevention, diagnosis, and treatment.

Read more about neglected tropical disease programs and networks

Resources for Researchers

NIAID provides a wide range of resources for every stage of the development pathway to facilitate and advance infectious disease research. These include repositories, genomics and bioinformatics services and tools, preclinical studies, and clinical trials. You may request services if you are an investigator in academia, a not-for-profit organization, industry, or government in the United States or worldwide. You need not be a grantee of NIAID or another National Institutes of Health Institute or Center. Look to each resource for further eligibility information.

For researchers developing products such as diagnostics, vaccines, or drug therapies, check out Support for Infectious Disease Product Developers.

See a full list of all neglected tropical diseases resources for research

Global Research Information for Researchers

Global research is an integral part of many research projects, programs, initiatives, and other activities implemented by the NIAID extramural and intramural divisions. The NIAID Office of Global Research (OGR) helps coordinate and facilitate these international activities.

Through the information offered here, researchers can learn about the science being conducted at NIAID and by NIAID-funded researchers. Researchers seeking funding can access opportunities to further their own research, while NIAID and NIH grantees can find out about available resources outside of specific funding opportunities. Recent publications, active networks, and ways to connect with other researchers are also available.

Funding Opportunities

NIAID is always accepting researcher-initiated applications. Check the NIAID International Awards section of the Research Funding website for resources, funding links, and contact information.

See a full list of global related Funding Opportunities

Resources for Researchers

NIAID offers resources such as technology for licensing or collaboration, computer applications, and other tools and services for the scientific community.

See a full list of resources for global researchers

Programs & Networks

NIAID participates in and supports research programs and networks that help to move global research forward.

See a list of programs and networks that fund global research

Connect With Other Researchers

Search for scientists at NIAID who are global researchers in the scientist directory.

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