NIH, GreenLight Biosciences to Collaborate on COVID-19 Vaccine Development for New Variants

Link Type
Funded-research
Media Type
Article
Publish or Event Date
Link URL
https://www.greenlightbiosciences.com/nih-greenlight-biosciences-to-collaborate-on-covid-19-vaccine-development-for-new-variants/
Research Institution
GreenLight Biosciences
Short Title
NIH, GreenLight Biosciences to Collaborate on COVID-19 Vaccine Development for New Variants
Content Coordinator
Claudia Wair
Content Manager
Catey Laube Macdonald

Variant Type and Patient Sex Affect Molnupiravir Efficacy, Study Finds

Tiny Fruit Fly Holds Major Genetic Transfer Discovery

Seeking Answers to Optimizing Influenza Vaccines in Older Adults through New Study

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Funded-research
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Article
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Link URL
https://today.uconn.edu/2022/08/seeking-answers-to-optimizing-influenza-vaccines-in-older-adults-through-new-study/
Research Institution
University of Connecticut
Short Title
Seeking Answers to Optimizing Influenza Vaccines in Older Adults through New Study
Content Coordinator
Claudia Wair
Content Manager
Kathy Donbeck

Developing Antivirals for Pandemic-Level Viruses

Universal Vaccine Needed to Prevent Future COVID-19 Waves, Study Suggests

Link Type
Funded-research
Media Type
Article
Publish or Event Date
Link URL
https://www.publichealth.columbia.edu/public-health-now/news/universal-vaccine-needed-prevent-future-covid-19-waves-study-suggests
Research Institution
Columbia University Mailman School of Public Health
Short Title
Universal Vaccine Needed to Prevent Future COVID-19 Waves, Study Suggests
Content Coordinator
Claudia Wair
Content Manager
Catey Laube Macdonald

New Method of Nasal Vaccine Delivery Could Lead to Better Vaccines for HIV and COVID-19

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Funded-research
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Article
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Link URL
https://twin-cities.umn.edu/news-events/new-method-nasal-vaccine-delivery-could-lead-better-vaccines-hiv-and-covid-19
Research Institution
University of Minnesota
Short Title
New Method of Nasal Vaccine Delivery Could Lead to Better Vaccines for HIV and COVID-19
Content Coordinator
Claudia Wair
Content Manager
Catey Laube Macdonald

Scripps Research Scientists Discover Antibodies that Induce Broad Immunity Against SARS Viruses, Including Emerging Variants

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Funded-research
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Article
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Link URL
https://www.scripps.edu/news-and-events/press-room/2022/20220810-andrabi-variants.html
Research Institution
Scripps Research
Short Title
Scripps Research Scientists Discover Antibodies that Induce Broad Immunity Against SARS Viruses
Content Coordinator
Claudia Wair
Content Manager
Catey Laube Macdonald

Fortress Biotech Subsidiary Helocyte Announces Grant that Could Provide Over $20 Million from National Institute of Allergy and Infectious Diseases for Phase 2 Study of Triplex for Control of Cytomegalovirus in Patients Undergoing Liver Transplantation

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Funded-research
Media Type
Article
Publish or Event Date
Link URL
https://www.fortressbiotech.com/investors/news-events/press-releases/detail/468/fortress-biotech-subsidiary-helocyte-announces-grant-that
Research Institution
Fortress Biotech
Short Title
Fortress Biotech Subsidiary Helocyte Announces Grant that Could Provide Over $20 Million in Patients Undergoing Liver Transplantation
Content Coordinator
Claudia Wair
Content Manager
Catey Laube Macdonald

Alexandra F. Freeman, M.D.

Section or Unit Name
Primary Immune Deficiency Clinic
Lab/Program Name
Laboratory of Clinical Immunology and Microbiology
First Name
Alexandra
Last Name
Freeman
Exclude from directory
Off
Section/Unit: Location
NIH Main Campus, Bethesda, MD
This Researcher/Clinician’s Person Page
Alexandra F. Freeman, M.D.
Parent Lab/Program
Laboratory of Clinical Immunology and Microbiology
Program Description

As a NIAID clinician, my main focus has been on the diagnosis, evaluation and management of individuals with defined and undefined primary immunodeficiencies (PIDs) with a particular focus on those with hyper IgE syndromes. STAT3 mutated Hyper IgE syndrome (STAT3 DN; Job’s syndrome) is associated with eczematous dermatitis, recurrent boils, recurrent sinopulmonary infections, and multiple connective tissues, skeletal and vascular abnormalities. This is a rare primary immune deficiency, and our center allows us to study the largest cohort in the US, and likely in the world.  We currently follow more than 100 individuals with STAT3 DN and provide clinical care to many when well and during acute illnesses.  Through laboratory collaborations over the years, we have sought to understand STAT3’s role on human immunity, airway infection susceptibility and wound and vascular remodeling. Although our understanding of the pathogenesis of STAT3 has increased in recent years, there are still many unresolved questions regarding the pathogenesis of the varied features and the optimal therapies, including the role of hematopoietic stem cell transplantation and gene editing. 

Clinical Studies

Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES) NCT00006150

Detection and Characterization of Infections and Infection Susceptibility NCT00404560

Study of Mycobacterial Infections NCT00018044

Detection and Characterization of Host Defense Defects NCT00001355

Selected Publications

Desai JV, Urban A, Swaim DZ, Colton B, Kibathi LW, Ferrè EMN, Stratton P, Merideth MA, Hunsberger S, Matkovits T, Mannino R, Holland SM, Tramont E, Lionakis MS, Freeman AF. Efficacy of Cochleated Amphotericin B in Mouse and Human Mucocutaneous Candidiasis. Antimicrob Agents Chemother. 2022 Jul 19;66(7):e0030822.

Delmonte OM, Bergerson JRE, Burbelo PD, Durkee-Shock JR, Dobbs K, Bosticardo M, Keller MD, McDermott DH, Rao VK, Dimitrova D, Quiros-Roldan E, Imberti L, Ferrè EMN, Schmitt M, Lafeer C, Pfister J, Shaw D, Draper D, Truong M, Ulrick J, DiMaggio T, Urban A, Holland SM, Lionakis MS, Cohen JI, Ricotta EE, Notarangelo LD, Freeman AF. Antibody responses to the SARS-CoV-2 vaccine in individuals with various inborn errors of immunity. J Allergy Clin Immunol. 2021 Nov;148(5):1192-1197.

Parisi X, Bergerson J, Urban A, Darnell D, Stratton P, Freeman AF. Obstetric and Gynecological Care in Patients with STAT3-Deficient Hyper IgE Syndrome. J Clin Immunol. 2020 Oct;40(7):1048-1050.

Freeman AF, Milner JD. The Child with Elevated IgE and Infection Susceptibility. Curr Allergy Asthma Rep. 2020 Aug 24;20(11):65.

Dmitrieva NI, Walts AD, Nguyen DP, Grubb A, Zhang X, Wang X, Ping X, Jin H, Yu Z, Yu ZX, Yang D, Schwartzbeck R, Dalgard CL, Kozel BA, Levin MD, Knutsen RH, Liu D, Milner JD, López DB, O'Connell MP, Lee CR, Myles IA, Hsu AP, Freeman AF, Holland SM, Chen G, Boehm M. Impaired angiogenesis and extracellular matrix metabolism in autosomal-dominant hyper-IgE syndrome. J Clin Invest. 2020 Aug 3;130(8):4167-4181.

Olbrich P, Freeman AF. STAT1 and STAT3 mutations: important lessons for clinical immunologists. Expert Rev Clin Immunol. 2018 Dec;14(12):1029-1041. 

Visit PubMed for a complete publication list.

Major Areas of Research

Hyper IgE Syndromes
Diagnosis and Treatment of Inborn errors of immunity
Susceptibility to Mycobacteria

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