Taming a Frenzied Immune System

Link Type
Funded-research
Media Type
Article
Publish or Event Date
Link URL
https://www.uoflnews.com/section/science-and-tech/taming-a-frenzied-immune-system-uofl-receives-6-1-million-to-research-immune-response-discovered-during-the-pandemic/
Research Institution
University of Louisville
Short Title
Taming a Frenzied Immune System
Content Coordinator
Claudia Wair
Content Manager
Catey Laube Macdonald

Family Resemblance—How T Cells Could Fight Many Coronaviruses at Once

Link Type
Funded-research
Media Type
Article
Publish or Event Date
Link URL
https://www.lji.org/news-events/news/post/family-resemblance-how-t-cells-could-fight-many-coronaviruses-at-once/
Research Institution
La Jolla Institute for Immunology
Short Title
Family Resemblance—How T Cells Could Fight Many Coronaviruses at Once
Content Coordinator
Claudia Wair
Content Manager
Catey Laube Macdonald

HIV/AIDS Scholars Using Nonhuman Primate (NHP) Models Program (K01 Independent Clinical Trial Not Allowed)

Gregory M. Constantine, M.D.

Section or Unit Name
Human Eosinophil Section
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Section/Unit: Location
NIH Main Campus, Bethesda, MD
This Researcher/Clinician’s Person Page
Gregory M. Constantine, M.D.
Parent Lab/Program
Laboratory of Parasitic Diseases
Program Description

Dr. Constantine’s research focuses on understanding tissue remodeling and neuroimmune mechanisms that may underpin ongoing symptoms in patients with gastrointestinal inflammatory (GI) conditions, including eosinophilic esophagitis (EoE) and other eosinophilic gastrointestinal diseases (EGID). Additionally, his research explores the influence of environmental factors, such as chemical exposures found in water systems and in processed food and food packaging, on gut inflammation.

Our clinical studies aim to improve EGID diagnosis through the implementation of minimally invasive diagnostic tools, such as the esophageal string test, ultimately enhancing patient care and outcomes.

In the Human Eosinophil Section, Dr. Constantine is an investigator on multiple protocols addressing eosinophilic disorders including eosinophilic esophagitis and other EGIDs and serves as a site-investigator for the Consortium of Eosinophilic Gastrointestinal Researchers (CEGIR) through NIH/NCATS/RDCRN.

Clinical Studies

Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia, NCT00001406, Associate Investigator

Zemaira Eosinophilic Esophagitis Pilot Study (ZEEPS), NCT05485155, Principal Investigator

Selected Publications

Wright BL, Abonia JP, Abud EM, Aceves SS, Ackerman SJ, Braskett M, Chang JW, Chehade M, Constantine GM, Davis CM, Dellon ES, Doyle AD, Durban R, Hill DA, Jensen ET, Kewalramani A, Khoury P, Klion AD, Kottyan L, Kuang FL, McGowan EC, Ruffner MA, Spencer LA, Spergel JM, Uchida AM, Wechsler JB, Pesek RD. Advances and ongoing challenges in eosinophilic gastrointestinal disorders presented at the CEGIR/TIGERs Symposium at the 2024 American Academy of Allergy, Asthma & Immunology meeting. J Allergy Clin Immunol. 2024 Oct;154(4):882-892.

Khalid MB, Sharma D, Howard A, Akbulut D, Sampaio de Melo M, Quezado MM, Castillo PA, Cuevas GA, Klion AD, Khoury P, Constantine GM, Kumar S. Gastrointestinal segmental remission with oral budesonide therapy for eosinophilic gastrointestinal diseases. J Allergy Clin Immunol Pract. 2024 Oct;12(10):2857-2860.e2.

Oikonomou V, Smith G, Constantine GM, Schmitt MM, Ferré EMN, Alejo JC, Riley D, Kumar D, Dos Santos Dias L, Pechacek J, Hadjiyannis Y, Webb T, Seifert BA, Ghosh R, Walkiewicz M, Martin D, Besnard M, Snarr BD, Deljookorani S, Lee CR, DiMaggio T, Barber P, Rosen LB, Cheng A, Rastegar A, de Jesus AA, Stoddard J, Kuehn HS, Break TJ, Kong HH, Castelo-Soccio L, Colton B, Warner BM, Kleiner DE, Quezado MM, Davis JL, Fennelly KP, Olivier KN, Rosenzweig SD, Suffredini AF, Anderson MS, Swidergall M, Guillonneau C, Notarangelo LD, Goldbach-Mansky R, Neth O, Monserrat-Garcia MT, Valverde-Fernandez J, Lucena JM, Gomez-Gila AL, Garcia Rojas A, Seppänen MRJ, Lohi J, Hero M, Laakso S, Klemetti P, Lundberg V, Ekwall O, Olbrich P, Winer KK, Afzali B, Moutsopoulos NM, Holland SM, Heller T, Pittaluga S, Lionakis MS. The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1. N Engl J Med. 2024 May 30;390(20):1873-1884.

Constantine GM, Khoury P. Overlap of eosinophilic esophagitis with inborn errors of immunity and immune dysregulation. J Allergy Clin Immunol. 2024 Jun;153(6):1529-1532.

Constantine GM, Klion AD. Recent advances in understanding the role of eosinophils. Fac Rev. 2022 Sep 27;11:26.

Constantine GM, Metcalfe DD, Akin C, Sun X, Bai Y, Eisch AR, Maric I, Komarow HD. Remission of indolent systemic mastocytosis in the absence of targeted therapy. J Allergy Clin Immunol Pract. 2022 Aug;10(8):2163-2165.e2.

Additional Information

Research Network

Consortium of Eosinophilic Gastrointestinal Researchers (CEGIR)

Major Areas of Research
  • Characterization and treatment of eosinophilic disorders, including eosinophilic esophagitis (EoE) and other eosinophilic gastrointestinal disorders (EGID), and hypereosinophilic syndromes (HES)
  • Sensory mechanisms of EGID-related symptoms
  • Role of environmental exposures on gut inflammation
  • Eosinophil biology and maturation 

New UCF-Developed Immunotherapy Treatment Targets Respiratory Viral Infections

Link Type
Funded-research
Media Type
Article
Publish or Event Date
Link URL
https://www.ucf.edu/news/new-ucf-developed-immunotherapy-treatment-targets-respiratory-viral-infections/
Research Institution
University of Central Florida College of Medicine
Short Title
New UCF-Developed Immunotherapy Treatment Targets Respiratory Viral Infections
Content Coordinator
Claudia Wair
Content Manager
Catey Laube Macdonald

Chemists’ Technique Reveals Whether Antibodies Neutralize SARS-CoV-2

Protein Nanoparticle Vaccine with Adjuvant Improves Immune Response Against Influenza, Biomedical Sciences Researchers Find

Link Type
Funded-research
Media Type
Article
Publish or Event Date
Link URL
https://news.gsu.edu/2023/05/10/protein-nanoparticle-vaccine-with-adjuvant-improves-immune-response-against-influenza-biomedical-sciences-researchers-find/
Research Institution
Institute for Biomedical Sciences at Georgia State University
Short Title
Protein Nanoparticle Vaccine with Adjuvant Improves Immune Response Against Influenza, Biomedical Sciences Researchers Find
Content Coordinator
Claudia Wair
Content Manager
Catey Laube Macdonald

Research in Mice Offers Clues for Vaccinating Against Deadly Bacteria

Link Type
Funded-research
Media Type
Article
Publish or Event Date
Link URL
https://medicine.wustl.edu/news/research-in-mice-offers-clues-for-vaccinating-against-deadly-bacteria/
Research Institution
Washington University School of Medicine in St. Louis
Short Title
Research in Mice Offers Clues for Vaccinating Against Deadly Bacteria
Content Coordinator
Claudia Wair
Content Manager
Catey Laube Macdonald

ABL Awarded Seven-Year NIH Contract for Continued Support in HIV Prevention Products

Link Type
Funded-research
Media Type
Article
Publish or Event Date
Link URL
https://ablinc.com/about-abl/news/news-item/abl-awarded-seven-year-nih-contract-for-continued-support-in-hiv-prevention-products/
Research Institution
Advanced BioScience Laboratories
Short Title
ABL Awarded Seven-Year NIH Contract for Continued Support in HIV Prevention Products
Content Coordinator
Claudia Wair
Content Manager
Catey Laube Macdonald

Aphios Awarded an NIH Grant to Develop a Double Encapsulated mRNA Vaccine For COVID-19 and Other Diseases

Link Type
Funded-research
Media Type
Article
Publish or Event Date
Link URL
https://aphios.com/press-release-articles/aphiosawardedannihgranttodevelopamrnavaccine/
Research Institution
Aphios
Short Title
Aphios Awarded a Grant to Develop a Double Encapsulated mRNA Vaccine For COVID-19
Content Coordinator
Claudia Wair
Content Manager
Catey Laube Macdonald
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