The purpose of this Notice of Funding Opportunity (NOFO) is to support applications for epidemiological and observational research projects on the long-term cardiopulmonary sequelae following treatment for tuberculosis (TB). Investigators should propose additional testing and data collection in existing cohorts of adult and/or pediatric TB participants to better characterize and understand adverse outcomes and morbidity associated with TB disease post treatment in individuals with and without HIV infection.
Dr. Sparks leads a multidisciplinary team of basic scientists, bioinformaticians, and clinical staff with the goal of using systems biology approaches to study the human immune system in health and disease. Her research focuses on (1) evaluation of both known and unknown immunological disorders to better understand the molecular underpinnings of these diseases, uncover correlates of disease subtypes to help improve diagnosis and prognosis, and identify potential novel treatment targets with the goal of therapeutic trials, and (2) using vaccination and systems immunology to probe the immune system of both healthy individuals and those with immunological disorders.
Sample collection from healthy volunteers for assay optimization (Principal Investigator; NCT03538600)
Systems analyses of the immune response to the seasonal influenza vaccine (Principal Investigator; NCT04025580)
Sample collection for systems evaluation of patients with unknown or incompletely characterized immune defects (Principal Investigator; NCT04408950)
A Phase 1/2 Open-label Study to Evaluate the Safety and Efficacy of Tofacitinib for Chronic Granulomatous Disease with Inflammatory Complications (Lead Associate Investigator: NCT05104723)