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Biocontainment Laboratory: University of Alabama at Birmingham Southeastern Biosafety Laboratory Alabama Birmingham (SEBLAB)

The regional biocontainment laboratory at University of Alabama at Birmingham (UAB), called Southeastern Biosafety Laboratory Alabama Birmingham (SEBLAB), is one of the NIAID-supported Biocontainment Laboratories. The Lab houses state-of-the art biosafety level 2 and level 3 laboratories as well as animal biosafety level 3 laboratories. SEBLAB's design includes flexible and secure laboratories, animal housing and procedure space, and laboratory support space

Main Areas of Focus

  • To provide surge capacity for diagnostics and other necessary analyses to enhance state and regional public health responses in the event of a bioterrorism emergency.
  • To lead investigation into new vaccines and explore the mechanisms by which infectious organisms function with the goal of developing methods to disrupt their life cycle and creating new treatments.

Who Can Use This Resource

  • Investigators in academia, not-for-profit organizations, industry, and government studying biodefense and emerging infectious diseases may request the use of biocontainment laboratories.

How To Get Started

  • Please contact SEBLAB directly for further information.

Support Services

Laboratory and Analytical Support

  • Pathology services: Comparative Pathology Laboratory (ARP)
  • Microbiology services: in house and Comparative Pathology Laboratory (ARP)

 Ability To Accommodate cGLP or cGMP Studies?

No.

Tools

Animal Capabilities, including species and containment level(s)

All available at BSL3/ABSL3 level

  • Mice
  • Rats
  • Guinea pigs
  • Hamsters
  • Ferrets
  • Rabbits
  • Nonhuman primates

Animal Models, including species, disease, and delivery method

  • Mice and ferrets (Highly Pathogenic Avian Influenza-aerosol, intranasal, intradermal)
  • Mice (Venezuelan and Eastern Equine Encephalomyelitis viruses, intranasal, subcutaneously)
  • Mice, guinea pigs (Mycobacterium tuberculosis, aerosol, intranasal, intratracheal)

Pathogens

  • Mycobacterium tuberculosis
  • Avian Influenza Viruses (including HPAI)
  • Venezuelan, Eastern and Western Equine Encephalomyelitis viruses
  • SARS CoV
  • MERS
  • West Nile
  • Chikungunya virus

Specialized Areas or Major Equipment Available

  • Glas-Col Inhalation Exposure System
  • Micro-injection system (Nikon dissection scope, micro-injector, micro-manipulator)

Shared Resources

The robust and dynamic UAB biomedical research/academic institution includes about 1.3M NASF of research, procedure and support space contiguous to the SEBLAB. The approximately 1000 scientists at UAB maintain approximately $400M in HHS funded research. The program includes many shared resources that could support the SEBLAB as needed and include the following:

  • SEBLAB Aerosol Core
  • Transgenic Animal/Embryonic Stem Cell Resource
  • Genetically Engineered Mutant Mouse Core Facility
  • Epitope Recognition Immunoreagent (Hybridoma) Core
  • Small Animal Imaging Core
  • Multi-Modality Imaging Core
  • Microsurgical Core
  • Small Animal Metabolic Phenotyping Core
  • Neuroscience Behavioral Phenotyping Core
  • Cellular and Synaptic Physiology Core
  • Flow Cytometry Core
  • Animal X-Ray Irradiator Resource
Content last reviewed on November 17, 2017