The Functional Genomics Program for understanding the functions of uncharacterized genes in infectious disease pathogens aims to generate experimental data to determine the biochemical function(s) of hypothetical genes, unknown open reading frames, and noncoding RNAs.
The program applies state-of-the-art technologies to determine the biochemical and physiological roles of these gene components. Obtaining a more comprehensive understanding of uncharacterized genes in infectious disease pathogens will lead to improved genomic annotation and allow for the development of potential new targets for medical diagnostics, therapeutics and vaccines.
Main Areas of Focus
- To obtain a more comprehensive understanding of uncharacterized genes in infectious disease pathogens
- To lead to improved genomic annotation and allow for the development of potential new targets for medical diagnostics, therapeutics and vaccines
- To distribute data, software, and reagents generated from research projects to the broader scientific community
Functional Genomics Steering Committee
The Functional Genomics Steering Committee was designed to review the progresss in meeting the program’s goals and made recommendations for the continuation or re-direction of all projects and activities on an ongoing basis and in consultation with the NIAID staff. The Steering Committee consisted of investigators who were not current collaborators of the funded centers.
- Josh Adkins – Pacific Northwest National Laboratory
- James Bliska – Stony Brook University
- Victor DiRita (Chair) – Michigan State University
- Jennifer Gardy – BC Centre for Disease Control
- Michael Laub – Massachusetts Institute of Technology
- Kathleen McDonough – Wadsworth Center NYSDOH
- Jim Musser – The Methodist Hospital
- David Pompliano – Third Rock Ventures
- Roz Sandri-Goldin – University of California Irvine
- Tom Slezak – Lawrence Livermore National Laboratory
- Sri Sreevatsan – University of Minnesota
- Renee Tsolis – University of California Davis
- Dave Wentworth (Vice-Chair) – CDC
Award Project Descriptions
The research activities were carried out by Harvard University School of Public Health, University of Chicago, University of North Carolina at Chapel Hill and University of Washington, see center websites for more detailed information projects and accomplishments.