GUNK center is part of the NIAID Functional Genomics Program. This center was created to investigate the role of previously uncharacterized genes of A. baumannii in its ability to cause human disease. Three projects have been established to:
- Use a genomic approach to broadly identify the role of uncharacterized genes.
- Determine the role of envelope integrity with regard to bacterial viability.
- Use expression analysis to identify genes and sRNAs of unknown function associated with drug, disinfectant, and desiccation tolerance.
Main Areas of Focus
- To deepen overall knowledge of genes of unknown function (GUF) that contribute to important phenotypes of clinical relevance in A. baumannii: antimicrobial resistance, innate immunity, and desiccation.
- To assign biochemical function(s) to proteins and sRNAs involved in these processes.
- To identify new antimicrobial targets in A. baumannii and the importance of its cell surface properties.
- To establish a pipeline for identification of new infectious disease drug targets and models to test their efficacy.
- Some of GUNK tools allow for new genomes to be added.
Who Can Use This Resource
- Available for public use.
How To Get Started
- Visit the GUNK website to access datasets and software.
- University of Washington
- Workshops are posted to the GUNK website.