HIV Database and Analysis Unit

The HIV Database & Analysis Unit provides an integrated repository of HIV sequence and immunology published data, by curating & maintaining a relational database with searchable web access for the scientific community; and (ii) develop web-based computation analysis methods and tools for researchers.

The database is located at the Los Alamos National Laboratory, New Mexico and aims to provide a centralized resource of global HIV sequence and immunology database for researchers to build upon the data previously collected and published in HIV scientific literature.

Main Areas of Focus

  • Data collection to provide comprehensive repository of HIV nucleotide sequences and immunological data
  • Curation, annotation, standardization, validation and quality control of sequences as data is uploaded into database
  • Access to relational database with searchable web access to extract and analyze data
  • Development of web based computation analysis methods and tools
  • Listing and providing links to external tools of significance in HIV informatics
  • Making the database information widely available and easily accessible to the research community
  • Publishing an annual HIV Sequence and Immunology Compendium, which is available free of charge

Tools

HIV Sequence Database tools are categorized to accomplish

  • Analysis and quality control
  • Alignment and sequence manipulation
  • Phylogenetics
  • Format and display

Collaboration Opportunities

  • Researchers who have submitted HIV sequences to GenBank can have them added to the HIV Database and Analysis Unit.

Who Can Use This Resource

  • Available for public use

Events

An annual database training and demonstration workshop is held Keystone symposia to:

  • Train researchers in the use of HIV sequence and immunology databases functionality
  • Publicize the availability of services offered
  • Solicit suggestions for improvement of the resource

Featured Research

  • Guiding scientific community to retrieve, align and analyze lentiviral sequences and immunological data from the relational database resource, to aid in the development of vaccines and therapies, and in understanding of pathology, genetics, and evolution of HIV
  • Currently HIV Sequence Database includes 754,034 sequences, while HIV Immunology Database lists 9,693 CTL epitopes, 1,579 T-helper epitopes and 3,122 Antibodies
  • Expanded scope of HIV Database and Analysis Unit includes (i) inclusion of anti-Env monoclonal antibody sequence data in HIV immunology database, and (ii) addition of a database of sequences from clonal lineages of HIV broadly neutralizing antibodies
  • Updated summary of data contained in database is published yearly in HIV Sequence and Immunology Compendium
  • Organize the database training and demonstration workshop annually at Keystone symposia to (i) train researchers in the use of HIV sequence and immunology databases functionality, (ii) publicize the availability of services offered, and (iii) solicit suggestions for improvement of the resource
Content last reviewed on November 17, 2017