This free resource offers easy searching of experimental data characterizing antibody and T cell epitopes studied in humans, non-human primates, and other animal species. T and B cell receptor sequences, when available, are curated with the relevant epitope record. The database contains detailed information for more than 2.2 million epitopes related to infectious, allergic, and autoimmune diseases and transplant rejection. The IEDB also provides tools to assist in the prediction, visualization, and analysis of immune epitopes.
More information about this resource is available at Immune Epitope Database and Analysis Resource (IEDB)
Note that the IEDB has a companion site funded by the National Cancer Institute called the Cancer Epitope Database and Analysis Resource (CEDAR), which houses cancer epitopes. In addition, HIV immune epitope information is available through the NIAID-funded HIV Molecular Immunology Database.
IEDB Program Objectives
- To disseminate immune epitope information supporting the NIAID mission in an easily accessible and downloadable format
- To facilitate immunology research and the development of new research tools, diagnostics, vaccines, and therapeutics
IEDB Analysis Resource Tools (selected)
- T Cell Epitope Prediction Tools
This set of tools includes MHC class I & II binding predictions, as well as peptide processing predictions and immunogenicity predictions. - B Cell Epitope Prediction Tools
The tools here are intended to predict regions of proteins that are likely to be recognized as epitopes in the context of a B cell response. - Epitope Analysis Tools
This is a suite of tools that facilitate detailed analyses and visualization of a known epitope sequence or group of sequences, including homology comparisons. - Immunome Browser
This tool is helpful to aggregate and visualize immune reactivity from epitope data in different assays/donors in given reference proteins using user-defined identity thresholds. The tool also accepts predicted epitopes.
Collaboration Opportunities
- Researchers can submit tools for inclusion in the IEDB here.
- Researchers can submit data directly to the IEDB: see the Data Submission Process.
- Application programming interface (API) for database available: Query API.
- Database may be licensed or downloaded: Customize Data Exports or submit a request.
Contact Information
Joseph Breen, Ph.D.
jbreen@niaid.nih.gov