Jack Bennink, Ph.D.

Jack Bennink, Ph.D.

Credit: NIAID

Major Areas of Research

  • Investigates the interaction between host immunity and viruses
  • Studies the biology and evolution of viruses with a primary emphasis on influenza virus evolution under immune (vaccination), partially immune, and non-immune selection pressures in vitro and in vivo
  • Studies innate and adaptive immunity with a focus on repertoire and the function of antiviral CD8+ T cells and B cells and their contribution to virus clearance and evolution
  • Investigates the cellular processing and presentation of viral antigens to major histocompatibility complex class I-restricted CD8+ T cells

View all Division of Intramural Research laboratories

Program Description

Virus infections within the human population impose a significant annual burden in morbidity, mortality, and economic loss. The immune system and viruses have evolved and continue to evolve in response to each other. The mission of the Viral Immunology Section is focused on extending our basic understanding of the interaction between the immune system and viruses.


Dr. Bennink obtained his Ph.D. from the University of Pennsylvania for the study of the specificity of virus immune effector T cells. He spent two years as a member of the Basel Institute for Immunology, followed by five years as assistant and associate professor at the Wistar Institute of Anatomy and Biology, before coming to the National Institute of Allergy and Infectious Diseases in 1987. His research focuses on influenza virus and antiviral immunity.

Research Group

Bernard Lafont, Ph.D.

Wei Wang, M.S.

Amanda Lawson, RLAT

Selected Publications

Yang N, Gibbs JS, Hickman HD, Reynoso GV, Ghosh AK, Bennink JR, Yewdell JW. Defining viral defective ribosomal products: standard and alternative translation initiation events generate a common peptide from influenza A virus M2 and M1 mRNAs. J Immunol. 2016 May 1;196(9):3608-17.

Frank GM, Angeletti D, Ince WL, Gibbs JS, Khurana S, Wheatley AK, Max EE, McDermott AB, Golding H, Stevens J, Bennink JR, Yewdell JW. A simple flow-cytometric method measuring B-cell surface immunoglobulin avidity enables characterization of affinity maturation to influenza A virus. MBio. 2015 Aug 4;6(4):e01156.

Brooke CB, Ince WL, Wei J, Bennink JR, Yewdell JW. Influenza A virus nucleoprotein selectively decreases neuraminidase gene-segment packaging while enhancing viral fitness and transmissibility. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16854-9.

Magadán JG, Altman MO, Ince WL, Hickman HD, Stevens J, Chevalier A, Baker D, Wilson PC, Ahmed R, Bennink JR, Yewdell JW. Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes. PLoS Pathog. 2014 Jun 12;10(6):e1004204.

Ince WL, Gueye-Mbaye A, Bennink JR, Yewdell JW. Reassortment complements spontaneous mutation in influenza A virus NP and M1 genes to accelerate adaptation to a new host. J Virol. 2013 Apr;87(8):4330-8.

Brooke CB, Ince WL, Wrammert J, Ahmed R, Wilson PC, Bennink JR, Yewdell JW. Most influenza A virions fail to express at least one essential viral protein. J Virol. 2013 Mar;87(6):3155-62.

Visit PubMed for a complete publication listing.

Content last reviewed on