Major Areas of Research
- Clinical disorders of the immune system in children, including allergic diseases and immunodeficiency diseases
- Atopic dermatitis and genetic disorders of allergic inflammation
- Genetic disorders of mast-cell homeostasis and activation in children and adults
- Graduate medical education in clinical immunology and allergy
Dr. Stone is the program director of the Allergy and Immunology Clinical Training Program.
Dr. Stone serves as a principal investigator on two protocols to support laboratory interests in the genetics and mechanisms of allergic inflammation in atopic dermatitis, severe atopic diseases, genetic disorders with features of allergic inflammation, and immunodeficiency diseases. He serves as a staff clinician working closely with Dr. Joshua Milner and the Genetics and Pathophysiology of Allergy Section of the Laboratory of Allergic Diseases, with a major interest in the advancement of research and clinical care for children with atopic dermatitis and other allergic and immunologic diseases.
Kelly Dean Stone, M.D., Ph.D., is a pediatric allergist/immunologist who serves as Deputy Chief and Senior Clinician in the NIAID Laboratory of Allergic Diseases, Director of the NIH Clinical Center Allergy and Immunology Clinical Fellowship Program, and Director of the NIH Clinical Center Allergy and Immunology Consultation Service.
Dr. Stone received his B.A. in Natural Sciences from Johns Hopkins University and his M.D. and Ph.D. in Molecular and Cell Biology from the University of Maryland School of Medicine. He completed residency training in Pediatrics at the Children’s National Medical Center and fellowship training in Allergy and Immunology at Children’s Hospital Boston. During his training, he was the recipient of the Robley Dunglison Award at the University of Maryland, the Maynard Cohen Memorial Award at Children’s National, and the Fred Rosen Fellowship in Immunology at Children’s Boston. He served on the faculty in the department of Pediatrics at Harvard Medical School/Children’s Hospital Boston and at George Washington University/Children’s National Medical Center, before joining the NIAID Division of Intramural Research in the Laboratory of Allergic Diseases in 2007.
Dr. Stone is principal investigator on protocols studying the genetics and pathogenesis of diseases of allergic inflammation, particularly atopic dermatitis, and has a major interest in the advancement of research and clinical care for children with allergic and immunologic diseases. He also has a primary focus on graduate medical education, serving as training program director at the NIH since 2008, chair of the Clinical Learning Environment Subcommittee of the NIH GME Committee, chair of the NIH Clinical Center’s Great Teachers Lecture Series, and as a speaker at national board reviews in pediatrics and allergy/immunology. He was a recipient of the 2012 NIH Director’s Ruth Kirschstein Mentoring Award and was a finalist for the 2012 NIH Clinical Center Distinguished Clinical Educator Award.
Dr. Stone serves on the Board of Directors of the American Academy of Allergy, Asthma, and Immunology; on the Accreditation Council for Graduate Medical Education’s (ACGME) Allergy and Immunology Review Committee; and on the ACGME Allergy and Immunology Milestones 2.0 Work Group. He is a member of the Clinical Immunology Society. He currently serves on the Allergenic Products Advisory Committee of the Food and Drug Administration and has served on the FDA Pulmonary and Allergy Drugs Advisory Committee.
Zhang Y, Yu X, Ichikawa M, Lyons JJ, Datta S, Lamborn IT, Jing H, Kim ES, Biancalana M, Wolfe LA, DiMaggio T, Matthews HF, Kranick SM, Stone KD, Holland SM, Reich DS, Hughes JD, Mehmet H, McElwee J, Freeman AF, Freeze HH, Su HC, Milner JD.Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment. J Allergy Clin Immunol. 2014 May;133(5):1400-9, 1409.e1-5.
Lyons JJ, Sun G, Stone KD, Nelson C, Wisch L, O'Brien M, Jones N, Lindsley A, Komarow HD, Bai Y, Scott LM, Cantave D, Maric I, Abonia JP, Rothenberg ME, Schwartz LB, Milner JD, Wilson TM. Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities. J Allergy Clin Immunol. 2014 May;133(5):1471-4.
Siegel AM, Stone KD, Cruse G, Lawrence MG, Olivera A, Jung MY, Barber JS, Freeman AF, Holland SM, O'Brien M, Jones N, Nelson CG, Wisch LB, Kong HH, Desai A, Farber O, Gilfillan AM, Rivera J, Milner JD. Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. J Allergy Clin Immunol. 2013 Dec;132(6):1388-96.
Lawrence MG, Barber JS, Sokolic RA, Garabedian EK, Desai AN, O'Brien M, Jones N, Bali P, Hershfield MS, Stone KD, Candotti F, Milner JD. Elevated IgE and atopy in patients treated for early-onset ADA-SCID. J Allergy Clin Immunol. 2013 Dec;132(6):1444-6.
Ombrello MJ, Remmers EF, Sun G, Freeman AF, Datta S, Torabi-Parizi P, Subramanian N, Bunney TD, Baxendale RW, Martins MS, Romberg N, Komarow H, Aksentijevich I, Kim HS, Ho J, Cruse G, Jung MY, Gilfillan AM, Metcalfe DD, Nelson C, O'Brien M, Wisch L, Stone K, Douek DC, Gandhi C, Wanderer AA, Lee H, Nelson SF, Shianna KV, Cirulli ET, Goldstein DB, Long EO, Moir S, Meffre E, Holland SM, Kastner DL, Katan M, Hoffman HM, Milner JD. Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med. 2012 Jan 26;366(4):330-8.