Major Areas of Research
- Characterization of antigen-specific lymphocyte function and differentiation in vivo, following vaccination or infection
- Identification of protective SIV and HIV envelope antibody responses
- Development of new single-cell measurement technologies
The Translational Research Program (TRP) serves three major functions at the VRC: 1) provides centralized support and service for all in vivo research conducted at the VRC, 2) conducts collaborative research and animal model development, and 3) operates a fully accredited lab animal facility.
TRP provides all aspects of oversight and programmatic assistance to support teaching, training, and in vivo research for the VRC by managing all preclinical safety and regulatory issues, ensuring judicious and humane use of animals in compliance with all institutional, local, state, and federal guidelines. It is the VRC primary resource for consultation, collaboration, and professional assistance in selecting appropriate animal models or establishing novel models to study disease and vaccine effects.
TRP pursues independent and collaborative research projects related to animal model and preclinical product development for HIV, influenza, emerging infectious diseases such as alphaviruses, and other biodefense-focused diseases. We conduct translational research to advance vaccine products from preclinical stages toward human clinical trials by actively monitoring and overseeing efficacy, safety, and toxicology studies in preparation for regulatory oversight of product development. TRP also investigates novel vaccine delivery methods to enhance efficiency, vaccine efficacy, and safety.
TRP serves as a fully accredited Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) in-house animal facility, adhering to all federal regulations. The facility provides quality animal husbandry services, veterinary care, and facility management support for rodents. The facility offers preventive medical care, routine surveillance, and quality assurance for vendor- and colony-produced animals and may also establish and maintain its own mouse breeding colonies if necessary. A variety of technical services are performed by facility staff, including parenteral injections or oral administration of Animal Care and Use Committee (ACUC)-approved experimental materials; blood, tissue, and serum collection; surgical manipulations; animal identification procedures; electroporation procedures; anesthesia/analgesic administration; and other procedures as needed. The veterinary care unit also offers training for those who wish to perform these procedures themselves. For VRC studies conducted at other facilities, TRP establishes contractual agreements and coordination between investigators and these facilities. Within the in-house facility and contracted facilities, TRP ensures high-quality research in accordance with regulatory guidelines and compliance with good laboratory practices (GLP) and biosafety level requirements as essential.
Dr. Roederer received his B.S. in chemistry in 1983 from Harvey Mudd College, Claremont, California, followed by his Ph.D. in biological sciences in 1988 from Carnegie Mellon, Pittsburgh, in the laboratory of Dr. Robert Murphy. He trained as a postdoctoral fellow and then as a research fellow at Stanford University from 1988 to 1999 in the laboratory of Dr. Leonard Herzenberg. Following this, he was adjunct associate professor, department of stomatology, University of California, San Francisco, until 2000, when he came to the VRC. He is a senior investigator and is chief of ITS, director of the Flow Cytometry Core, and director of the Nonhuman Primate Immunogenicity Core within the Laboratory of Immunology.
Roederer, M., Quaye, L., Mangino, M., Beddall, M. H., Mahnke, Y., Chattopadhyay, P., Tosi, I., Napolitano, L., Terranova Barberio, M., Menni, C., Villanova, F., Di Meglio, P., Spector, T. D. and Nestle, F. O. (2015). The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis(link is external). Cell, 161, 387-403.
Roederer, M. (2015). Parsimonious Determination of the Optimal Infectious Dose of a Pathogen for Nonhuman Primate Models(link is external).PLoS Pathog, 11, e1005100.
Roederer, M., Keele, B. F., Schmidt, S. D., Mason, R. D., Welles, H. C., Fischer, W., Labranche, C., Foulds, K. E., Louder, M. K., Yang, Z. Y., Todd, J. P., Buzby, A. P., Mach, L. V., Shen, L., Seaton, K. E., Ward, B. M., Bailer, R. T., Gottardo, R., Gu, W., Ferrari, G., Alam, S. M., Denny, T. N., Montefiori, D. C., Tomaras, G. D., Korber, B. T., Nason, M. C., Seder, R. A., Koup, R. A., Letvin, N. L., Rao, S. S., Nabel, G. J. and Mascola, J. R. (2014). Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV(link is external). Nature, 505, 502-8.
Chattopadhyay, P. K., Gierahn, T. M., Roederer, M. and Love, J. C. (2014). Single-cell technologies for monitoring immune systems(link is external). Nat Immunol, 15, 128-35.
Dominguez, M. H., Chattopadhyay, P. K., Ma, S., Lamoreaux, L., McDavid, A., Finak, G., Gottardo, R., Koup, R. A. and Roederer, M. (2013). Highly multiplexed quantitation of gene expression on single cells(link is external). J Immunol Methods, 391, 133-45.
Lugli, E., Dominguez, M. H., Gattinoni, L., Chattopadhyay, P. K., Bolton, D. L., Song, K., Klatt, N. R., Brenchley, J. M., Vaccari, M., Gostick, E., Price, D. A., Waldmann, T. A., Restifo, N. P., Franchini, G. and Roederer, M. (2013). Superior T memory stem cell persistence supports long-lived T cell memory(link is external). J Clin Invest, 123, 594-9.