Multiproject Awards SOP

This standard operating procedure (SOP) includes the following sections: Purpose, Procedure, Contacts, and Links.

Some links will work for NIAID staff only.


To provide grant funding to at least two related research projects.


You may apply for a multiproject grant in one the following two ways:

  1. Respond to a request for applications (RFA) for a program project or cooperative agreement.
  2. Submit an application for an investigator-initiated P01 program project grant, e.g., the NIAID Investigator-Initiated Program Project Applications (P01) funding opportunity announcement (FOA).

Note: Do not submit an application that proposes a clinical trial unless the FOA explicitly states that it accepts clinical trials.

Multi​project grant types include

  • P01 grant—multidisciplinary, long-term program headed by a PI or PIs who bring in other investigators to conduct research projects and share resources. For an investigator-initiated application, go to the NIAID Investigator-Initiated Program Project Applications (P01) FOA.
  • P30 grant—center core grant that supports shared resources and facilities for a multidisciplinary research team or group of investigators focusing on a common research topic.
  • P50 grant—specialized center award that supports a multidisciplinary group of investigators who share a common research topic.
  • U19 cooperative agreement—award for multidisciplinary projects that require substantial involvement from NIAID staff. See our description of Substantial Staff Involvement at Determining When to Use a Cooperative Agreement.
  • U54 cooperative agreement—support for research and development from basic to clinical, including ancillary supportive activities that create a multidisciplinary focus on a disease or a biomedical problem. Centers may also serve as regional or national resources for special research purposes.
  • UM1 cooperative agreement—support large-scale cooperative agreements involving complex clinical trials with multiple components, e.g., clinical networks.
  • UM2 cooperative agreement—support for large-scale centers with complicated structures that cannot be appropriately categorized into an available multicomponent activity code, e.g., clinical networks, research programs, or consortiums.

Please note that the NIH big grant policy applies to multiproject applications, as described below.


  • Read the RFA or program announcement you are responding to thoroughly for eligibility conditions.
  • Unless the FOA you are responding to explicitly states that it accepts clinical trials, do not submit an application that proposes a clinical trial.
  • RFA or program announcement, read it thoroughly for eligibility conditions.
  • Read Multiproject Research (P, U) Applications for NIAID-specific instructions.
  • For an investigator-initiated P01 application, contact an NIAID program officer when still in the planning stage to assess the likelihood of our approval of your idea.
    • NIAID must approve your application before you apply, indicating that we agree to allow Center for Scientific Review to assign it here for possible funding.
    • Your application must include a cover letter from an NIAID program officer that approves the submission.
    • For an overview on submitting an application, see P01 Program Project Grants.
  • For any multiproject application, you must get an NIAID program officer's approval six weeks before submitting if your application requests direct costs of $500,000 or more in any year of the grant, even if none of the individual projects request that much.
    • If you are requesting close to $500,000, read our Big Grants SOP for guidance.
    • Even if you plan to request under $500,000, we strongly encourage you to discuss your idea with an NIAID program officer when still in the planning stage.
  • Program Staff

    • Document your approval by following the procedures in the Big Grants SOP.
  • Contacts

    If you have knowledge to share or want more information on this topic, email with the title of this page or its URL and your question or comment. Thanks for helping us clarify and expand our knowledge base.


    Selecting Unsolicited P01 Applications for Award SOP

    Program Announcements (PA) SOP

    Requests for Applications (RFA) SOP

Content last reviewed on January 13, 2017