The Non-Obese Diabetic (NOD) mouse, which spontaneously develops type 1 diabetes, is a valuable animal model that is used extensively in research exploring the etiology, prevention, and treatment of this disease. It is a vital research tool for testing promising prevention and treatment strategies at the preclinical level.
The NOD mouse BAC library contains 240,000 clones obtained from the Diabetes and Inflammation Laboratory (Cambridge, United Kingdom).
Main Areas of Focus
- To provide a better understanding of potential immunogenomic loci responsible for the initiation and progression of autoimmune destruction of insulin-producing β-cells, eventually paving the way to potential targets in therapy.
- Two NOD mouse BAC libraries
- NOD mouse BAC end-sequences
- Clone map from these two libraries
- Analyzed and manually annotated sequences