This core serves as a national resource for the long-term care and study of animals after irradiation, since 2007. The Radiation Late Effects Program facilitates the conduct of late-stage preclinical studies of mitigators of radiation damage in nonhuman primates. Because of the high degree of genetic and physiologic similarity of nonhuman primates to human beings, this resource is a critical component of translational long-term assessment of candidate radiation mitigators, in an experimental setting under which relevant doses of whole-body irradiation and partial body irradiation with 5% bone marrow sparing can be studied in otherwise healthy subjects.
More information about this resource is available at Radiation Survivor Late Effects Cohort
Main Areas of Focus
Core investigators have unique skills in the experimental use and clinical medicine of nonhuman primates including
- Veterinary medical care and management of myelosuppressed animals
- Comparative pathology of primates
- Pathology of radiation injury
- Biochemistry
- Clinical pathology and endocrinology of primates
- Adaptation of molecular biologic techniques to the primate model
- Microbiome sequencing and analysis
Support Services
- Acquire and provide long term care of rhesus macaque nonhuman primates
- Perform minimally invasive studies (e.g., vaccination, blood collection, biopsy)
- Administer therapeutic interventions
- Conduct clinical and pathologic assessments of treatment outcomes, including necropsy/tissue collection, for characterization of long-term radiation responses and assessment of mitigating interventions
- Sharing of data and samples (CBC/chem data, imaging data [CT, MRI, DEXA] and fluid and tissue samples)
- Data management services for primate studies, including data and tissue sharing
Tools
- Database of nonhuman primate observational data
- Tissue repository of both irradiated and age-matched control rhesus macaques
Eligibility Criteria
Each request for access to resources is reviewed on a case-by-case basis.
How To Get Started
Researchers request data or samples using the request page found here. For information about collaborations and other support services, please contact the Wake Forest Core Director listed on their website.
Assurance to Requestors
AAALAC Accreditation
Research Network Affiliation
This irradiated nonhuman primate sample and data resource is supported by funding from the NIAID Radiation and Nuclear Countermeasures Program.
Featured Research
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Location
Wake Forest University