U.S. President's Emergency Plan for AIDS Relief (PEPFAR)

PEPFAR is the U.S. government initiative to help save the lives of those living with and affected by HIV/AIDS around the world. This historic commitment is the largest by any nation to combat a single disease internationally, and PEPFAR investments also help alleviate suffering from other diseases across the global health spectrum. PEPFAR is driven by a shared responsibility among donors, host countries, and other partners to make smart investments to save lives and, ultimately, end the AIDS epidemic by 2030.

Main Areas of Focus

  • To identify the most successful and cost-effective strategies for reaching at-risk populations for HIV prevention and treatment interventions
  • To control and ultimately end the HIV/AIDS epidemic


PEPFAR is led and managed by the U.S. Department of State's Office of the U.S. Global AIDS Coordinator and Health Diplomacy and implemented by seven U.S. government departments and agencies, leveraging the power of a whole-of-government approach to controlling the HIV/AIDS epidemic.


PEPFAR has funded Implementation Science grants through a series of individual NOFOs, released by NIH, CDC, and/or USAID.

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