The SVEU conducts preclinical studies to evaluate candidate SIV or HIV vaccines in nonhuman primates (NHPs). The SVEU contractor will immunize the animals and together with the SVEU Core Laboratories: Humoral Immunology, Cellular Immunology, and Functional Omics, evaluate immune responses that the NHPs generate in response to the vaccines. Additionally, following vaccination, the SVEU can challenge the animals with SIV or SHIV virus. In conjunction with the SVEU Virology Core Laboratory, the levels of replicating virus post-challenge will be determined to assess vaccine efficacy.
Main Areas of Focus
- To evaluate promising SIV and HIV vaccines in nonhuman primates in support of HIV vaccine development
Support Services
- Preliminary studies on new vaccine candidates
- Efficacy studies with vaccines that have already demonstrated promise
- Studies with passively administered products
- In vivo titration of virus challenge stocks
- Evaluation of the immunogenicity and efficacy of candidate HIV vaccines or SIV vaccines (that parallel HIV vaccines in approach) in support of Phase I human clinical trials
- Comparative studies on vaccines and/or adjuvants from multiple sources
Who Can Use This Resource
- This resource is open to all AIDS researchers who are conducting preclinical AIDS vaccine research.
- Investigators must have preliminary data on the immunogenicity of their candidate vaccine and must be able to provide information on the relevant properties of their candidate vaccine, including details of the vaccine content/construction, the level of expression of HIV and/or SIV immunogens (for DNA, RNA, vector-base vaccines), purity (for protein immunogens), the dose and route of delivery proposed, and other relevant data.
- If approved for a SVEU study, it is expected that the investigator will try to publish the results.
How To Get Started
Contact NIAID SVEU staff to request more information and/or request a proposal application form.
Email: SVEU@niaid.nih.gov
Proposals from investigators are evaluated by NIAID and approved studies are conducted at a SVEU contract site. SVEUs conduct collaborative studies in which the vaccine investigator works together with the SVEU Principal Investigator and the SVEU Project Officer on the study design and data evaluation.
Assurance to Requestors
- Investigators are assured that they will be collaborators in the conduct of the studies conducted by the SVEU contractor, that data from their study will be treated in a confidential manner, and that they will be responsible for ensuring presentation and publication of the study results take place in a timely manner.
Contact Information
- Dr. Nancy Miller