Database of Mutations Causing Human Hyper IgE Syndrome (STAT3base)

The STAT3base contains a listing of STAT3 mutations in human HIES identified in the Laboratory of Clinical Immunology and Microbiology as well as those published in the literature.

    Main Areas of Focus

    • To demonstrate critical regions of the protein and sites of recurrent mutations resulting in HIES.


    • Schematic of mutations causing HIES
    • Distribution of STAT3 mutations causing HIES
    • Clinical features list
    Content last reviewed on November 17, 2017