Systems Biology and Antibacterial Resistance Program

There are six sites that conduct systems biology research specific to antimicrobial resistance (AMR). The purpose of these projects is to identify, quantify, model, and predict the molecular interactions of AMR bacterial pathogens and their host during infectious disease initiation and progression or in response to antibacterial treatment. (Funding opportunity announcement RFA-AI-14-064)


  • Baylor College of Medicine; Decoding Antibiotic-Induced Susceptibility to Clostridium difficile Infection
    • Contact PI: Tor Savidge
    • Project PI: Robert Britton 
    • Project PI: Kevin Garey
    • Project PI: Dimitrios Iliopoulos
    • Project PI: Joseph Sorg
  • Boston College; Predicting the Emergence of Antibiotic Resistance through Multi-Omics Approaches and Immune System Surveillance  
    • Contact PI: Tim Opijnen
    • Project PI: Jose Bento
    • Project PI: Vaughn Cooper
    • Project PI: Ralph Isberg
    • Project PI: Jason Rosch
  • Sloan Kettering Institute for Cancer Research; Systems Biology of Microbiome-Mediated Resilience to Antibiotic Resistant Pathogens
    • Contact PI: Eric Pamer
    • Project PI: Joao Xavier
  • Los Angeles Biomedical Institute at Harbor - UCLA Med; Systems Immunolobiology of Antibiotic-Persistent MRSA Infection
    • Contact PI: Michael Yeaman
    • Project PI: Vance Fowler
    • Project PI: Elaine Reed
  • University of California, San Diego; Systems Biology Approach To Redefine Susceptibility Testing and Treatment of MDR Pathogens in the Context of Host Immunity
    • Contact PI: Bernhard Palsson
  • University of Michigan; Systems Biology of Clostridium difficile Infection
    • Contact PI: Vincent Young
    • Project PI: Patrick Schloss


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