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Women's Interagency HIV Study (WIHS)

The Women's Interagency HIV Study (WIHS), established in 1993, is a multi-center, prospective, observational cohort study of women living in the United States who are either HIV-infected or at risk for HIV acquisition.  WIHS plays an important role in NIAID’s effort to understand the current epidemiology of HIV infection, disease progression, treatment use and outcomes, and related co-morbidities among U.S. residents with HIV.  Understanding differences in HIV disease and treatment outcomes between women compared to men, and in different racial and ethnic groups, is a critical public health goal. The WIHS is currently conducted at ten clinical research sites (CRSs), each of which is representative of the population of HIV-infected women in or out of care within their geographical region. This clinical research consortium is an integral part of the NIAID portfolio of research on HIV in women.

 

Main Areas of Focus

  • To understand the current epidemiology of HIV infection, disease progression, treatment use and outcomes, and related co-morbidities among HIV-positive individuals in the United States
  • To understand the differences in HIV disease and treatment outcomes between women compared to men and in different racial and ethnic groups
  • To further understanding on how to achieve optimal therapy effectiveness
  • To study the uptake of antiretroviral medications
  • To study the predictors of successful and sustained viral suppression
  • To conduct research to define the clinical outcomes for women with HIV across their full lifespan

Oversight

The WIHS Executive Committee (EC) is responsible for managing the overall scientific aims of the WIHS and is composed of the Principal Investigators (PIs) from each awardee institution, a WIHS community advisory board member selected by study subjects to represent their interests, and a Project Scientist from each current co-funding NIH Institute.

Locations
  • Montefiore Medical Center/Einstein University - Bronx, NY
  • SUNY Downstate - Brooklyn, NY
  • Hektoen Research Center - Chicago, IL
  • Georgetown University - Washington, DC
  • University of California - San Francisco, CA
  • University of North Carolina - Chapel Hill, NC
  • Emory University - Atlanta, GA
  • University of Miami - Miami, FL
  • University of Alabama – Birmingham, AL/University of Mississippi Medical Center - Jackson, MS
  • Since 1997 the WIHS data management and analysis center (WDMAC) has been located at the Johns Hopkins University Bloomberg School of Public Health - Baltimore, MD
Featured Research

The WIHS Dossier contains a list of ongoing and completed core aims and substudies, cohort and retention status, baseline characteristics, mortality rates, and ARV use status. The Dossier also summarizes key study characteristics and scientific contributions from WIHS publications. The Dossier is updated annually and can be found on the WIHS website. 

Content last reviewed on November 17, 2017