Zoonotic Influenza Vaccine Seed Viruses

This resource provides Good Manufacturing Practice (GMP)-quality candidate vaccine viruses for zoonotic influenza, a critical component of global influenza pandemic preparedness. Candidate vaccine viruses have been used to create H5, H9, and H7 vaccine lots that have been deployed to national stockpiles and/or clinical trials.

More information about this resource is available at World Health Organization

Main Areas of Focus

  • To provide GMP-quality candidate vaccine viruses for zoonotic influenza


  • Candidate vaccine viruses repository:
    • Candidate vaccine viruses are developed by St. Jude Children’s Research Hospital (SJCRH), one of the NIAID Centers of Excellence for Influenza Research and Surveillance. The production and dissemination of these candidate vaccine viruses is coordinated by the World Health Organization (WHO) through their Global Influenza Surveillance and Response System program, of which the NIAID contractors at SJCRH are major participants.
  • Reagent grade viruses are also available to researchers upon request

Who Can Use This Resource

  • GMP viruses will be sent only to vaccine manufacturers.
  • Specific permits, which include verification of proper laboratory facilities, are required prior to virus being shipped.
  • GMP viruses fall under the WHO Pandemic Influenza Preparedness framework. Requestors must agree to enter into standard material transfer agreement negotiations with WHO.

How To Get Started

  • Requestors should contact Dr. Richard Webby, SJCRH for GMP vaccine strain references.
  • SJCRH will require the requestor to provide documentation that the receiving site has the appropriate importation documents, laboratory, and permits for receiving the material. SJCRH will work with NIAID to review the request. If the request is approved, SJCRH will ship the material on behalf of NIAID/National Institutes of Health.