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Dean D. Metcalfe, M.D., is the Chief of Mast Cell Biology Section. The mast cell is the focus of the Mast Cell Biology Section (MCBS) research effort. This multifunctional inflammatory cell is involved in both innate and acquired immunity and plays a central role in the induction of allergic inflammation.
Last Reviewed: May 19, 2022
An integrated program investigating mast cell biology includes studies into growth & differentiation of mast cells, mast-cell signal transduction, & products generated by mast cells that lead to disease. MCBS emphasizes basic research that may be translated to the clinic & the bench. Protocols include studies on the pathogenesis of anaphylaxis, physical urticarias & clonal mast cell disorders.
Last Reviewed: October 6, 2022