The core services team provides cell culture, hematology, hemostasis, clinical chemistry, microbiology, and molecular virology support for infectious disease studies at the IRF-Frederick. The team has the ability to perform pre-screening assessment by having parallel setups of clinical analyzers in biosafety level 4 (BSL-4) and BSL-2. In addition, the team processes a high volume of study samples and maintains a repository from which it provides experimental samples to other groups within the facility for downstream analysis.

Developing, characterizing, and refining animal models rely on sophisticated medical imaging equipment; aerosol capabilities; and virology, pathology, molecular biology, and immunology expertise. Animal models are key to advancing medical countermeasures for high-consequence pathogens and often provide the only opportunity to gain critical insights and develop clinical algorithms for effectively managing patients or establishing a regulatory pathway for product licensure.

The aerobiology team develops aerosol animal models of disease caused by high-consequence pathogens. Using advanced inhalational technologies, this team provides high experimental reproducibility to ensure the best modeling possible. Aerosolization procedures are fine-tuned to achieve accurate and precise dosimetry. All work with high-consequence pathogens is conducted within animal biosafety level 4 (ABSL-4) containment laboratories at the Integrated Research Facility at Fort Detrick (IRF‑Frederick).

The Systems Biology Consortium for Infectious Diseases is a community of systems biologists who integrate experimental biology, computational tools and modeling across temporal and spatial scales to improve our understanding of infectious diseases. Through collaborative efforts, scientists test and validate hypotheses that drive innovation and discovery. The Consortium seeks to develop strategies that predict and alleviate disease severity and ultimately provide solutions to the world's most important health challenges.

The Therapeutic Development Services program offers a collection of preclinical services to support the development of products intended for use in the cure, mitigation, diagnosis, or treatment of disease caused by a pathogen or certain toxins.

This is one of several programs provided by NIAID's Division of Microbiology and Infectious Diseases to support infectious disease product developers.

The Vaccine and Treatment Evaluation Units (VTEUs), supported by the Division of Microbiology and Infectious Diseases (DMID) since the 1960s, provide a ready resource for the conduct of clinical trials to evaluate promising vaccines, treatments, and diagnostics for infectious diseases. The sites are part of DMID's Infectious Diseases Clinical Research Consortium (IDCRC).

The WRCEVA program maintains the Emerging Viruses and Arboviruses Reference Collection and provides reagents and support for investigations of virus outbreaks throughout the world. 

The Vaccine Development Services program offers a collection of preclinical services to support the development of vaccines intended for use in the investigation, control, prevention, and treatment of a wide range of infectious agents (other than HIV).

This is one of several programs provided by NIAID's Division of Microbiology and Infectious Diseases to support infectious disease product developers.

Therapeutic Development Services - Interventional Agents program provides services to facilitate preclinical development of therapeutics and new in vivo diagnostics for infectious pathogens, including bacteria, viruses, parasites, fungi, and toxins. Services will be conducted at the appropriate regulatory compliance level dependent on the stage of product development.

Note: Devices are excluded.

The In Vitro Assessment for Antimicrobial Activity program provides capability in a broad range of in vitro assessments to evaluate promising candidate countermeasures for antimicrobial activity against microbial pathogens and vectors, including those derived from clinical specimens.

This is one of several programs provided by NIAID's Division of Microbiology and Infectious Diseases to support infectious disease product developers.