The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has established a network of research sites to study the natural history, transmission and pathogenesis of influenza and provide an international research infrastructure to address influenza outbreaks.

This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation.

This protocol is designed to study the techniques needed to develop gene therapy or other treatments for certain inherited immune system diseases.

This study will examine the symptoms, course of disease and treatment of non-tuberculous mycobacterial (NTM) infections, as well as the genetics involved in these infections.

The pathogenesis of this disease and long-term natural history is being investigated. Therefore, we seek to enroll patients and families with a confirmed or suspected diagnosis of HIES syndrome for extensive phenotypic and genotypic study as well as disease management. 

The goal of this study is to enhance understanding of the demographic, immunologic, and metabolic characteristics of individuals at risk for developing type 1 diabetes.

Simmune is a suite of software tools that guides the user through the multiple hierarchical scales of cellular behavior, facilitating the generation of comprehensive models. It was originally created to simulate immunological phenomena—hence its name, Simmune—but it is applicable to a very broad class of cell biological models.

Heterogeneity in Human Immune Cells is a website providing interactive figures (iFigs) for a recent study of protein expression heterogeneity in human immune cells conducted by Dr. John Tsang's group (Systems Genomics and Bioinformatics Unit) at the Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases and the Trans-NIH Center for Human Immunology.

Researchers involved with the NIAID Clinical Genomics Program study many diseases of the immune system that are rare and not well understood but that often shed light on basic immune function and more common immune disorders. This research is carried out across multiple labs, disease processes, and with many different tools.

The NIAID Clinical Genomics Program centralizes resources to be used for genomics and related research.

The STAT3base contains a listing of STAT3 mutations in human HIES identified in the Laboratory of Clinical Immunology and Microbiology as well as those published in the literature.