Dr. Manion performs research in the HIV Pathogenesis Section under the direction of Dr. Irini Sereti where the laboratory's focus is on the inflammatory complications in HIV, particularly looking at immune reconstitution inflammatory syndrome (IRIS) and non-infectious complications like cardiovascular disease.

Dr. Manion’s specific focuses in the laboratory is the characterization of the immune response during IRIS in patients with immunocompromised states other than HIV infection and investigating the consequences and management of inflammation of HIV-1 infection. Dr. Manion is an investigator on a protocol focused on paradoxical reactions in patients with tuberculosis.

Dr. Manion is the government supervisor to the NIAID clinical fellows, and she serves as core faculty for the ACGME accredited fellowship training programs in allergy immunology and infectious diseases. 

Dr. Manion earned her medical degree at Case Western Reserve University, and she underwent her internal medicine residency training at Case Western University Hospitals Cleveland Medical Center. She completed her fellowship training in infectious disease at NIAID.

Manion M, Dulanto Chiang A, Pei L, Wong CS, Khil P, Hammoud DA, Anderson M, Laidlaw E, Kuriakose S, Lisco A; NISC Comparative Sequencing Program, Zelazny AM, Dekker JP, Sereti I. Disseminated Mycobacterium marinum in Human Immunodeficiency Virus Unmasked by Immune Reconstitution Inflammatory Syndrome. J Infect Dis. 2021 Aug 2;224(3):453-457.

Manion M, Lynn N, Pei L, Hammoud DA, Laidlaw E, Roby G, Metzger D, Mejia Y, Lisco A, Zelazny A, Holland S, Vachon ML, Scherer M, Bergin C, Sereti I. To Induce Immune Reconstitution Inflammatory Syndrome or Suppress It: The Spectrum of Mycobacterium genavense in the Antiretroviral Era. Clin Infect Dis. 2021 Jan 27;72(2):315-318.

Manion M, Dimitrova D, Pei L, Gea-Banacloche J, Zelazny A, Lisco A, Zerbe C, Freeman AF, Holland SM, Kanakry CG, Kanakry JA, Sereti I. Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium. Clin Infect Dis. 2020 Feb 3;70(4):676-679.

Manion M, Uldrick T, Polizzotto MN, Sheikh V, Roby G, Lurain K, Metzger D, Mican JM, Pau A, Lisco A, Laidlaw E, Hammoud DA, Whitby D, Yarchoan R, Sereti I. Emergence of Kaposi's Sarcoma Herpesvirus-Associated Complications Following Corticosteroid Use in TB-IRIS. Open Forum Infect Dis. 2018 Oct 12;5(10):ofy217.

Manion M, Hullsiek KH, Wilson EMP, Rhame F, Kojic E, Gibson D, Hammer J, Patel P, Brooks JT, Baker JV, Sereti I; Study to Understand the Natural History of HIV/AIDS in the Era of Effective Antiretroviral Therapy (the ‘SUN Study’) Investigators. Vitamin D deficiency is associated with IL-6 levels and monocyte activation in HIV-infected persons. PLoS One. 2017 May 2;12(5):e0175517.

Manion M, Andrade BB, DerSimonian R, Gu W, Rupert A, Musselwhite LW, Sierra-Madero JG, Belaunzaran-Zamudio PF, Sanne I, Lederman MM, Sereti I. Country of residence is associated with distinct inflammatory biomarker signatures in HIV-infected patients. J Virus Erad. 2017 Jan 1;3(1):24-33. PMID: 28275455; PMCID: PMC5337418.

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