See the list of NIAID clinical trials that are recruiting in the United States below or view the complete list of NIAID studies clinical studies on ClinicalTrials.gov.
Search Results
112 Results
A Biorepository of Multiple Allergic Diseases (MADREP) With Longitudinal Follow-Up
To create a repository of clinical, laboratory, and diagnostic data and specimens from a cohort of suspected or confirmed atopic or allergic individuals with diverse disorders seen by allergist-immunologists and rhinologists.
A Clinical Trial to Evaluate the Safety and Immunogenicity of CH505M5 N197D mRNA-gp160 Followed by CH505 TF mRNA-gp160 in Adults in Overall Good Health Without HIV
The objective of this study is to evaluate the safety and immunogenicity of CH505M5 N197D mRNA-gp160 and CH505 TF mRNA-gp160.
A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations
The purpose of this study is to determine whether patients who have been infected with the Lyme bacteria, Borrelia burgdorferi, and treated with antibiotics still have the bacteria alive inside them and whether it is causing their symptoms.
A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults
This is a prospective, single-arm study designed to understand the mechanisms that lead to a loss of response to influenza vaccine in older adults.
A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression
The purpose of this study is to investigate FE and its genetic causes, damage mechanisms, and disease markers (such as blood test abnormalities).
A phase 2 open-label study to evaluate the efficacy and safety of ruxolitinib on hair regrowth in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)- associated alopecia areata
The purpose of this study is to see if a study drug (ruxolitinib) can help hair regrowth in people with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)-associated alopecia areata (AA) and if it can improve other symptoms caused by the immune system s attack to the body.
A Repository to Study Host-Microbiome Interactions in Health and Disease
The purpose of this study is to collect microbiome samples from the body that can be used for future research.
A Study of VRC07-523LS, PGT121.414.LS, and PGDM1400LS Broadly Neutralizing Monoclonal Antibodies Given Intravenously in Adult Participants Without HIV
HVTN 206/HPTN 114 is a randomized, double blind, controlled, phase 2 clinical trial to evaluate the safety, tolerability, pharmacokinetics, and neutralization of VRC07-523LS, PGT121.414.LS, and PGDM1400LS broadly neutralizing monoclonal antibodies given intravenously in adult participants without HIV. The hypothesis of the study is that the combination of VRC07-523LS and PGT121.414.LS and PGDM1400LS antibodies when administered via the intravenous (IV) route will be safe and tolerable in adult participants without HIV. The study aims to enroll 200 participants across multiple sites with an estimated total duration of participation of eighteen (18) months.
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of ALG-097558 in Subjects with Renal Impairment and in Healthy Subjects with Normal Renal Function
The primary purpose of this study is to characterize the effect of renal impairment on the plasma pharmacokinetics of ALG-097558 following administration of multiple, twice daily (Q12H) oral (PO) doses.
A Study to Evaluate the Safety and Immunogenicity of Two Doses of DCVC H1 HA mRNA-LNP in Healthy Adults
The primary objective of this study is to assess the safety of two doses of DCVC H1 HA mRNA vaccine administered intramuscularly in healthy adults (18-49 yrs) at dosage levels of 10 mcg, 25 mcg, and 50 mcg.
Admission and Management of Occupational or Other Exposures to Biodefense/Bioterrorism Agents or to Epidemic/Emerging Infectious Diseases
The objective of this study is to apply standardized, documented, and carefully monitored evaluation and treatment methods for bioterrorism- and biodefense-related illnesses and emerging infectious diseases at the National Institutes of Health Clinical Center.
Adolescent Master Protocol for Participants 18 Years of Age and Older (AMP Up)
This is a prospective cohort study designed to define the impact of HIV infection and antiretroviral therapy (ART) on young adults with perinatal HIV infection (YAPHIV) as they transition into adulthood. A group of of perinatally exposed but uninfected young adults from a similar sociodemographic background and age distribution will be enrolled for comparison.
Allogeneic Regulatory Dendritic Cell (DCreg) Renal Study
This study will evaluate the safety and feasibility of treatment involving a single infusion of donor-derived regulatory dendritic cells (DCreg) in first time, living donor renal transplant recipients.
Apheresis and Specimen Collection Procedures to Obtain Plasma, Peripheral Blood Mononuclear Cells (PBMCs) and Other Specimens for Research Studies
This study collects specimens such as blood, urine, body fluids or secretions, skin swabs, or skin biopsies from volunteers for use in studies by the Vaccine Research Center. The samples are used for medical research, including the study of HIV, hepatitis, and other diseases; immune system responses, such as responses to vaccinations or infections; and for research on vaccine development.
Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies
The purpose of this study is to collect blood plasma and white blood cells from individuals for laboratory research studies.
Bone Marrow and Peripheral Blood Immune Responses Study
The purpose of this study is to evaluate the immune response of the killed flu vaccine in healthy subjects.
Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults
In this study, the investigators will measure influenza virus cellular and humoral immune responses in individuals of different birth years before and after influenza vaccination.
Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates
The goal of the study is to evaluate the impact of the intervention on bacterial contamination of water supply, on staff hands, and on high-touch surfaces in maternity wards.
Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HxB2.WT.Core-C4b Boosts, Both Adjuvanted With 3M-052 AF + Alum, in Adult Participants Without HIV and in Overall Good Health
This is a partially randomized, open-label phase 1 study to evaluate the safety and immunogenicity of a priming regimen of 426c.Mod.Core-C4b adjuvanted with 3M-052 AF + Alum followed by boosts with HxB2.WT.Core-C4b adjuvanted with 3M-052 AF + Alum. The primary hypothesis is that the boosting with HxB2.WT.Core-C4b adjuvanted with 3M-052 AF + Alum will further mature broadly neutralizing antibody (bnAb)-precursor B-cell lineages elicited by 426c.Mod.Core-C4b adjuvanted with 3M-052 AF + Alum. 426c.Mod.Core-C4b adjuvanted with 3M-052 AF + Alum has been tested in HVTN 301 previously, whereas the HxB2.WT.Core-C4b will be first-in-human (FIH).
Collection of Human Biospecimens for Basic and Clinical Research into Globin Variants
The purpose of the study is collect samples to use for research on blood disorders.
Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System
This study will compare tests performed on both healthy volunteers and individuals who have signs or symptoms of immune-related damage to their central nervous system (CNS).
Consent for Use of Stored Patient Specimens for Future Testing
The purpose of this study is to obtain informed consent to use stored human biological materials (HBM) (e.g., blood and other tissues) for future studies that may include genetic testing.
COVID-19-Acute, Recovered and Vaccination Specimen Collection
The NIAID Vaccine Research Center is looking for volunteers who have been recently infected with or have recovered from COVID-19 infection. We are also looking for those that plan to receive or received a COVID Vaccine to donate blood for research.
Crossover Study of On-Demand Prep Formulations Comparing Rectal and Oral Tenofovir
This is a Phase 2, multi-site, two-period, open label randomized crossover (Period 1 and 2) study.
Cryptococcosis Study
This NIAID study is investigating why some people who are healthy and have normal immune function become infected with cryptococcosis.