Cryptococcosis Study

What is the cryptococcosis study?

This study is investigating why some people who are healthy and have normal immune function become infected with cryptococcosis. Cryptococcosis is a fungal infection that typically affects people with HIV, cancer, or other conditions that weaken the body’s immune system. The infection can progress to pneumonia and meningitis, which may cause serious symptoms of lung, brain, and spinal cord disease, such as headaches, fever, cough, shortness of breath, confusion, and weakness. People who recover from cryptococcal meningitis often need long-term treatment with medication to prevent the infection from coming back. This study may help National Institutes of Health (NIH) researchers in Bethesda, Maryland, learn why some previously healthy individuals get infected with Cryptococcus—information that may help develop better treatment and prevention strategies for patients in the future.

Who can participate?

You may be eligible to participate if you

  • Are 18 years of age or older
  • Have previously had or currently have cryptococcosis or cryptococcal meningitis
  • Do not have another condition that puts you at risk for cryptococcosis (e.g., HIV, corticosteroid therapy, cancer)

What does the study involve?

Study participants will receive free, expert medical care from an experienced team of healthcare professionals. Participants will visit the NIH Clinical Center for the initial appointment and then at least twice a year to monitor their health and to receive medical evaluations. Medical evaluations and procedures will vary based on a patient’s disease course and may include blood draws, lumbar puncture, and genetic testing.

Where is the study taking place?

The study is being conducted at the NIH Clinical Center in Bethesda, Maryland. The NIH campus is accessible by car and public transportation.

How much does it cost?

There is no charge to participate in this research study. All study-related medical care, including clinic visits, procedures, and medications, are provided free of charge.

Will I receive payment?

No, you will not be compensated for your participation in the study. Transportation and other expenses may be covered.

To learn more about this study of patients with cryptococcosis (trial ID: NCT00001352), visit

Contact Information

If you have questions or would like more information, contact

Office of Patient Recruitment
Toll Free: 1-800-411-1222
TTY: 1-866-411-1010
Se habla español.

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