The original MACS collected and stored a variety of biological specimens. Inventory may be housed at the national level or a subset at the local level. The now combined MACS-WIHS Combined Cohort Study (MWCCS) Data Analysis and Coordinating Center (DACC) coordinates and facilitates completion of specimen requests.
More information about this resource is available at Multicenter AIDS Cohort Study Specimen Repository
Main Areas of Focus
- To promote the widest possible range of uses of MACS specimens for current and future investigations that will expand current understanding of the epidemiology of HIV infection, disease progression, treatment use and outcomes, and related co-morbidities among HIV-positive individuals
- To provide the platform for other HIV-related NIH-funded grants
- To enable the evolution of a substantial clinical research database
- To foster the development of the next generation of observational and clinical epidemiologists by remaining at the forefront in the collection and statistical analysis of observational data
Tools
MACS National/Central Repository
Specimen types available:
- Serum
- Plasma
- Viable cells (PBMCs)
- Dry cell pellets
- Urine (whole and supernatant)
- Saliva
- Semen
- Stool
Local/Clinical Site Repositories
- Some specimen derivatives are stored locally, as well as various subsets of the national specimen inventory
- If the MACS-WIHS CCS DACC deems no National Repository specimens to be available, specimens can be sought from local/clinical site repositories
- The Clinical Site Principal Investigator or Project Director will coordinate access
MACS DNA Repository
- DNA and/or existing genomics/GWAS data are available only from participants who provided appropriate consent for genetic studies
Contact the MACS-WIHS CCS DACC for details on how to access isolated DNA and/or cell pellets from immortalized B-cell lines that may be available.
Who Can Use This Resource
- Investigators wishing to access specimens should contact the MACS-WIHS CCS NHLBI Program Officer for details on how to access.
How To Get Started
- Visit the MACS-WIHS CCS website to get started.
Contact Information
- Joana D'Arc Roe
- Rosemary McKaig
- Robin Huebner