NIAID Role in Research

Improving the health of millions of people around the world

NIAID conducts and supports basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases. For more than 60 years, NIAID research has led to new therapies, vaccines, diagnostic tests, and other technologies that have improved the health of millions of people in the United States and around the world. NIAID is one of the 27 Institutes and Centers of the National Institutes of Health (NIH).

NIAID Research Areas

HIV/AIDS

NIAID is working to better understand HIV and how it causes disease, find new tools to prevent HIV infection, develop new and more effective treatments for HIV-infected people, and find a cure.

Infectious Diseases

NIAID conducts and supports research on nearly 300 infectious agents and investigates the biological properties of these pathogens and the immune system’s responses to them. Findings from this research are vital to NIAID efforts to create vaccines, drugs, and diagnostic tools to better diagnose, prevent, and treat infectious diseases.

Allergy, Immunology, & Transplantation

NIAID supports basic and clinical research to increase our understanding of the causes and mechanisms that lead to the development of allergic and immunologic diseases and to expand knowledge that can be applied to improving techniques of diagnosis, treatment, and prevention.

Research Disciplines & Approaches

The pursuit of NIAID’s research mission requires innovation, collaboration, and broad-mindedness. Researchers both working at NIAID and being funded by NIAID use a wide range of approaches to their research pursuits. Disciplines that cut across and beyond individual diseases or conditions form an important part of our research agenda.

NIAID Research Infrastructure

Research Conducted in NIAID Labs

NIAID supports 25 laboratories, two free-standing sections, and two independent programs that conduct peer-reviewed research, as well as several branches that focus on new research technologies and animal care. Through the Division of Intramural Research and Vaccine Research Center, principal investigators lead research groups composed of staff scientists, physicians, fellows, technical personnel, and students. In addition to conducting internal research, NIAID provides many laboratory and clinical research training opportunities for both pre- and postdoctoral physicians and scientists.

Funding for Research

NIAID supports research at external academic and research institutions through funding opportunities including grants, contracts, and cooperative agreements. Decades of NIAID-funded research has helped further the understanding, diagnosis, and treatment of many of the world's most intractable and widespread conditions in the areas of allergy, immunology and infectious diseases. In addition to targeted requests for proposals in response to initiatives, NIAID is always accepting researcher-initiated applications. Connect with NIAID program officers about potential funding.

Resources for Researchers

In addition to monetary funding, NIAID or NIAID-funded groups provide services that are available to the research community to advance their scientific pursuits.  You may request services if you are an investigator in academia, a nonprofit organization, industry, or government in the United States or worldwide. You need not be a grantee of NIAID or another National Institutes of Health Institute or Center. Look to each resource for further eligibility information.

Programs & Networks

Programs and networks help to increase collaboration, break down silos, and share information and data by connecting researchers to each other, to institutions public and private, and to the general scientific community. A research program or network is an umbrella organizing group, internal or external to NIAID, whose responsibilities include to conduct, oversee, and at times fund research or offer non-monetary support for research. Most of these programs or networks offer services, i.e., resources, available to the NIAID scientific community.

Partnerships

When appropriate, NIAID works with partners to help fund initiatives, drive campaigns, and ultimately push forward research related to the NIAID mission.

NIAID Accomplishments

mRNA chromosomes

Decades in the Making: mRNA COVID-19 Vaccines

Decades of NIH-supported laboratory research laid the groundwork for the rapid development of mRNA vaccines in the first 100 days of the COVID-19 pandemic. Today, two U.S. Food and Drug Administration (FDA)-approved mRNA vaccines have saved millions of lives.

Safe and Effective RSV Protein Vaccines

NIAID-funded basic and clinical studies helped establish the fundamental knowledge necessary for the private sector to develop protein vaccines. These vaccines are safe and effective at preventing severe RSV in some target populations.

First FDA-Approved Drug for Delaying T1D Onset

NIH-funded research helped pave the way for development of Teplizumab, the first FDA-approved therapeutic for delaying type 1 diabetes (T1D) onset in at-risk patients. This delay reduces the potential for severe long-term complications in patients, thereby improving their quality of life.

See all NIAID Accomplishments

Immune System Information for Researchers

Through the information offered here, researchers can learn about the science being conducted at NIAID and by NIAID-funded researchers. Researchers seeking funding can access opportunities to further their own research, while NIAID and NIH grantees can find out about available resources outside of specific funding opportunities. Recent publications, active networks, and ways to connect with other researchers are also available.

Support for Research

Resources for Researchers

NIAID offers resources such as technologies available for licensing or collaboration, computer applications, and other tools and services to the general scientific community to advance basic, preclinical, and clinical research. See all resources for immune system researchers.

Connect with Other Researchers

Programs and Networks

See a full list of NIAID-supported programs and networks that further immune system research.

Fungal Diseases Information for Researchers

Globally, more than 1 billion people get a fungal infection each year, according to the Centers for Disease Control and Prevention. Some fungal infections are more common in people with weakened immune systems or hospitalized individuals, while other fungal infections can infect anyone, including otherwise healthy people. There are only four classes of antifungal drugs, and fungal strains resistant to these drugs are emerging. Currently, there are no approved vaccines to prevent fungal infections. The ultimate objective of NIAID-supported research is to develop effective diagnostics, treatments, and preventives.

Through the information offered here, researchers can learn about the science being conducted at NIAID and by NIAID-funded researchers. Researchers seeking funding can access opportunities to further their own research, while NIAID and NIH grantees can find out about available resources outside of specific funding opportunities, and ways to connect with other researchers are also available.

Funding Opportunities

NIAID is always accepting researcher-initiated applications. Connect with NIAID program officers about potential funding for fungal disease research. Program Officers for can be found in the Bacteriology and Mycology Branch of the Division of Microbiology and Infectious Diseases (DMID). 


Search our funding opportunities for fungal disease-related grants

Connect With Other Researchers

Search for scientists at NIAID who research fungal diseases in the scientist directory.

Search for scientists funded by NIAID who fungal diseases on RePORTER. 

Resources for Researchers

NIAID offers resources such as technologies available for licensing or collaboration, computer applications, and other tools and services to the general scientific community to advance basic, preclinical, and clinical research. Look to each resource for eligibility information. See all fungal disease researchers

For researchers developing products such as diagnostics, vaccines, or drug therapies, check out NIAID's support for infectious disease product developers.

NIAID Office of Research Training and Development

Our Mission

The mission of the NIAID Office of Research Training & Development (ORTD) is to

  • Promote and support biomedical education and training of fellows in the NIAID intramural research program
  • Design and implement training courses and career development workshops for current NIAID trainees
  • Provide opportunities for exploration in a variety of career paths
  • Encourage trainee development by providing mentoring opportunities and collaborative interactions
  • Conduct outreach programs in different communities to promote diversity at all training levels

While You're Training at NIAID

ORTD offers additional opportunities to learn about your field, network, and refine your skills such as:

  • Ethics Workshop for summer students
  • Annual Fellowship Workshop
  • Research seminars
  • NIAID grant writing training & mentoring
  • Clinical case reviews
  • Introduction to Clinical Reasoning
  • Virtual career/alumni chats
  • Asynchronous training opportunities
  • One-on-one career coaching
  • Grad school and medical school prep seminars and coaching

Summer Research Training in NIAID Labs

Updates on Recruitment

The Intramural Program has paused the recruitment of specific training programs—for the latest updates and details, visit the NIH Office of Intramural Training & Education.

Summer research training at NIAID is available through the Summer Internship Program (SIP). Summer programs offer students the opportunity to conduct research at the forefront of immunologic, allergic, and infectious diseases in NIAID laboratories located in Maryland and Montana (Rocky Mountain Laboratories in Hamilton). Summer interns spend a minimum of eight consecutive weeks performing full-time biomedical research in basic, translational, and clinical research areas under the guidance and direction of an NIAID principal investigator. Interns participate and engage with other trainees and scientists in a wide variety of research and professional development events during their time at NIH. The summer internship program strives to offer a stimulating and highly rewarding experience for interns, with the aim of encouraging students to pursue a career in biomedical research.

Read more about the Division of Intramural Research and the Vaccine Research Center. Find more information about the summer internship programs from the NIH Office of Intramural Training and Education (OITE).

Who Can Apply

Applicants must:

  • Be a U.S. citizen or permanent resident
    • Individuals who are U.S. permanent residents must be attending or have been accepted into institutions in the United States
  • Be 18 years of age or older on June 1 of the internship year

In addition, applicants must meet one of the following criteria at the time of application:

  • Be a current high school senior
  • Be a high school graduate and have been accepted into an accredited college or university program in the following fall semester
  • Be a current undergraduate, master’s, Ph.D., M.D., or equivalent graduate degree student

Applicants with a family member working at NIH should be aware of the strict nepotism policy, which may limit your ability to work in certain NIH institutes, centers, or research groups.

Note: Please refer to OITE for more details.

Background Check

Please note any fellowship offer is contingent on your ability to successfully pass a federal background check, which is required for logical and physical access to NIH facilities and systems. As part of the clearance process, you will be asked “In the last year, have you used, possessed, supplied, or manufactured illegal drugs?” This question pertains to the use of controlled substances or drugs as defined under federal law. Please be aware that while marijuana may be legal or decriminalized within your home jurisdiction it remains illegal under U.S. federal law. The use, possession, supply, or manufacture of marijuana may preclude you from obtaining the necessary clearances to participate in NIH intramural training programs, even if you were initially offered a position. If you have questions about this policy or would like guidance on the clearance process, please reach out to oite@nih.gov (please put “Eligibility Inquiry” in the subject line).

How To Apply

For specific questions, contact the NIAID Office of Research Training & Development.

Stipend Information

Stipend levels for trainees are published annually and determined based on experience. For details, see NIH Student IRTA Stipend levels.

Contact Information

For specific questions, contact the NIAID Office of Research Training & Development.

Clinical Product Development Services for Infectious Disease Research

Prion Diseases Information for Researchers

NIAID scientists have focused research on prion structures, biochemistry, cell biology, pathogenesis, diagnostics, and therapeutics. NIAID also is exploring similarities between prion diseases and other protein misfolding diseases, such as Alzheimer’s and Parkinson’s diseases, Lewy body dementia, and chronic traumatic encephalopathy, and is supporting research on transmission and incidence of infections.

Through the information offered here, researchers can learn about the science being conducted at NIAID and by NIAID-funded researchers. Researchers seeking funding can access opportunities to further their own research, while NIAID and NIH grantees can find out about available resources outside of specific funding opportunities. Recent publications, active networks, and ways to connect with other researchers are also available.

Support for Research

Resources for Researchers

NIAID offers resources such as technologies available for licensing or collaboration, computer applications, and other tools and services to the general scientific community to advance basic, preclinical, and clinical research. See all resources for prion disease researchers.

For researchers developing products such as diagnostics, vaccines, or drug therapies, check out NIAID's support for infectious disease product developers.

Funding Opportunities

Contact the Virology Branch within the Division of Microbiology and Infectious Diseases to learn about possible funding opportunities.

Rodolfo Alarcon, Ph.D., Program Officer, Virology Branch


Search all NIAID funding opportunities and announcements

Connect with NIAID Researchers

Dengue Fever Information for Researchers

Recognizing the threat to public health posed by dengue, NIAID funds over 200 hundred dengue research projects, including studies on dengue hemorrhagic fever and dengue shock syndrome, the most severe forms of the disease. NIAID research priorities include effective community-based prevention programs, improved laboratory-based international surveillance, rapid diagnostic tests and therapies, and development of and clinical trials for dengue vaccines.

Through the information offered here, researchers can learn about the science being conducted at NIAID and by NIAID-funded researchers. Researchers seeking funding can access opportunities to further their own research, while NIAID and NIH grantees can find out about available resources outside of specific funding opportunities. Recent publications, active networks, and ways to connect with other researchers are also available.

Support for Research

Funding Opportunities

Contact the Virology Branch (VB) within the Division of Microbiology and Infectious Diseases to learn about possible funding opportunities for research on dengue viruses. If you are interested in funding opportunities for vector research, please contact the Parasitology and International Programs Branch (PIPB).


Search all NIAID funding opportunities and announcements

Resources for Researchers

NIAID offers resources such as technologies available for licensing or collaboration, computer applications, and other tools and services to the general scientific community to advance basic, preclinical, and clinical research. Look to each resource for eligibility information. See all resources for dengue fever researchers

For researchers developing products such as diagnostics, vaccines, or drug therapies, check out NIAID's support for infectious disease product developers.

Connect with NIAID Researchers

Programs & Networks

NIAID encourages partnerships among other agencies and foundations, private industry, federal and local government and other organizations with similar goals to help build and sustain research infrastructure and to translate and implement research findings as public health practices.


Read more about NIAID-supported programs and networks that further dengue fever and related diseases research

Preclinical Product Development Services for Infectious Disease Research

The Division of Microbiology and Infectious Diseases (DMID) has built a comprehensive set of preclinical services to facilitate efforts to develop the next generation of vaccines, diagnostics and therapeutics for a broad array of bacterial, viral, fungal and parasitic pathogens, as well as novel control approaches for invertebrate vectors of public health importance. Through these in-kind services, eligible investigators worldwide get access to expertise, research materials, and state-of-the-art technologies at minimal or no charge.

Information about available services, eligibility, product evaluation criteria, and the request process are unique to each program. DMID scientific contacts are listed for each resource and are available to answer questions and provide further guidance about access to these resources. 

  • In Vitro Assessments of Antimicrobial Activity. These services evaluate promising candidate countermeasures in vitro for antimicrobial activity against microbial pathogens and vectors, including clinical isolates.
  • Preclinical Models of Infectious Diseases. These services support (1) the development and refinement of animal models and animal replacement technologies and (2) provide testing in animal models and human microphysiological systems (MPS) — against priority viruses only — including organ-on-a-chip and organoid-based infection models for promising candidate countermeasures.
  • Therapeutic Development Services. These services support the testing and manufacturing of therapeutic agents for infectious diseases, such as small molecules, peptides, monoclonal antibodies, recombinant proteins, and nucleic acid-based vectors (siRNA, plasmids). Services include chemistry and manufacturing, and preclinical safety and pharmacokinetic studies for IND packages (such as ADMET, off-target toxicity profiling, and MTD studies).
  • Vaccine Development Services. These services support the testing and manufacturing of vaccines intended for use in the investigation, control, prevention, and treatment of a wide range of infectious agents.
  • Diagnostics Development Services. These services offer reagents, platform testing, and planning and design support to accelerate product development of in vitro diagnostics for infectious diseases, from research feasibility through clinical validation.

Additional Resources for Early Preclinical Development

The following resources may have different access processes than the core preclinical services listed above. Please refer to the links below for more information:

Antibacterial Resistance Leadership Group (ARLG) Biorepository

The Antibacterial Resistance Leadership Group (ARLG) Laboratory Center manages a biorepository of bacterial clinical study isolates that are available upon request to investigators. The ARLG Biorepository Strain Catalogue can be used to search for available isolates.

BEI Resources

BEI Resources Repository supplies organisms and reagents to the broad community of microbiology and infectious diseases researchers. Investigators can access materials directly through an online catalog. There is no charge for research materials, but domestic investigators will be required to pay for shipping costs. BEI Resources also encourages and supports the deposit of materials from researchers and institutions.

Bioinformatics Resource Centers (BRCs)

The NIAID Bioinformatics Resource Centers (BRCs) provide data-driven, production-level, sustainable computational platforms to enable sharing, accessing, and analyzing data with various analytical tools and educational materials that support interoperability for the infectious diseases research community. 

Centers for Research on Structural Biology of Infectious Diseases (CRSTAL-ID)

The NIAID Centers for Structural Biology of Infectious Diseases (CRSTAL-IDs) characterize the 3D structure of proteins from bacterial, viral, and eukaryotic pathogens using state-of-the-art technologies from computational modeling, x-ray crystallography, NMR and CryoEM. The CRSTAL-IDs additionally have the capacity for supporting the discovery of therapeutics and vaccines using structural-guided design and high throughput chemical screening platforms. Investigators can contact the CRSTAL-ID centers directly to access expert services and to request determinations of protein structures.

Chemistry Center for Combating Antibacterial Resistant Bacteria

The Chemistry Center for Combating Antibacterial Resistant Bacteria (CC4CARB) is an innovative chemistry center focused on the synthesis, acquisition, and distribution of rationally designed, focused libraries for use in Gram-negative antibacterial drug discovery programs at no cost to the global scientific community. The ultimate objective of CC4CARB is to create a large collection of chemical matter specifically targeting Gram-negative antimicrobial drug discovery. Investigators may submit their scaffold proposals for chemical synthesis directly to the CC4CARB website.

Dataset of NCI’s Natural Product Library Screen for Antimicrobial Activity

In collaboration with the National Cancer Institute's (NCI) Program for Natural Product Discovery (NPNPD), NIAID screened one of the largest publicly available collections of natural products against three bacterial and one fungal species. A publication on the screening process and results can be found on PubMed. The screening dataset and instructions for contacting NCI’s Natural Products Branch to acquire natural product libraries or extracts of interest can be found on the NCI wiki.

World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)

The World Reference Center for Emerging Viruses and Arboviruses (WRCEVA) program maintains the Emerging Viruses and Arboviruses Reference Collection and provides reagents and support for investigations of virus outbreaks throughout the world. 

Contact Your Program Officer To Discuss Scientific Services

Contact DMID staff for more information about scientific services.