Type 1 Diabetes Extension Study (T1DES)

The goal of this study is to further the understanding of the immunologic mechanisms underlying maintenance and loss of beta cell function by evaluating the relationship between longitudinal changes in beta cell function and changes over time in biomarkers known to be associated with a response to immune modulating treatments used in prior clinical trials.

Study of Mycobacterial Infections

This study will examine the symptoms, course of disease and treatment of non-tuberculous mycobacterial (NTM) infections, as well as the genetics involved in these infections.

Contact Information

Merertu Tesso, (301) 402-7831
tessom@mail.nih.gov

Steven M Holland, M.D., (301) 402-7684
sholland@mail.nih.gov

Study of Clinical Features and Genetics of Hyperimmunoglobulin E Recurrent Infection

The pathogenesis of this disease and long-term natural history is being investigated. Therefore, we seek to enroll patients and families with a confirmed or suspected diagnosis of HIES syndrome for extensive phenotypic and genotypic study as well as disease management.

Contact Information

Christine J Lafeer, R.N., (301) 761-6902
clafeer@niaid.nih.gov

Alexandra Freeman, M.D., (301) 594-9045
freemaal@mail.nih.gov

TrialNet Pathway to Prevention of Type 1 Diabetes

The goal of this study is to enhance understanding of the demographic, immunologic, and metabolic characteristics of individuals at risk for developing type 1 diabetes.

Contact Information

TrialNet Central Information Center
1-800-425-8361

Selected Clinical Trials About HIV/AIDS

NIAID is committed to conducting the research necessary to confront HIV/AIDS. Volunteer participation in a clinical research study helps NIAID better understand HIV, find promising new tools to prevent HIV infection including a vaccine, and develop new and more effective treatment strategies.

Read more about Selected Clinical Trials About HIV/AIDS

TRITON Study

We are studying a condition called paradoxical reaction that some people get when they take treatment for tuberculosis (TB). Most people with TB feel better after starting treatment. But for some people, the opposite happens. They may feel better at first, but then suddenly get worse. This opposite effect is a paradoxical reaction. We do not understand how this reaction happens. It can be hard to tell whether worsening symptoms are caused by a paradoxical reaction or something else, such as if the treatment just is not working.