These programs and networks provide further information on NIH’s and the US federal government’s efforts in advancing behavioral and social sciences and HIV biomedical clinical research.
Dr. Manion performs research in the HIV Pathogenesis Section under the direction of Dr. Irini Sereti where the laboratory's focus is on the inflammatory complications in HIV, particularly looking at immune reconstitution inflammatory syndrome (IRIS) and non-infectious complications like cardiovascular disease.
Dr. Manion’s specific focuses in the laboratory is the characterization of the immune response during IRIS in patients with immunocompromised states other than HIV infection and investigating the consequences and management of inflammation of HIV-1 infection. Dr. Manion is an investigator on a protocol focused on paradoxical reactions in patients with tuberculosis.
Dr. Manion is the government supervisor to the NIAID clinical fellows, and she serves as core faculty for the ACGME accredited fellowship training programs in allergy immunology and infectious diseases.
Dr. Manion earned her medical degree at Case Western Reserve University, and she underwent her internal medicine residency training at Case Western University Hospitals Cleveland Medical Center. She completed her fellowship training in infectious disease at NIAID.
Manion M, Dulanto Chiang A, Pei L, Wong CS, Khil P, Hammoud DA, Anderson M, Laidlaw E, Kuriakose S, Lisco A; NISC Comparative Sequencing Program, Zelazny AM, Dekker JP, Sereti I. Disseminated Mycobacterium marinum in Human Immunodeficiency Virus Unmasked by Immune Reconstitution Inflammatory Syndrome. J Infect Dis. 2021 Aug 2;224(3):453-457.
Manion M, Lynn N, Pei L, Hammoud DA, Laidlaw E, Roby G, Metzger D, Mejia Y, Lisco A, Zelazny A, Holland S, Vachon ML, Scherer M, Bergin C, Sereti I. To Induce Immune Reconstitution Inflammatory Syndrome or Suppress It: The Spectrum of Mycobacterium genavense in the Antiretroviral Era. Clin Infect Dis. 2021 Jan 27;72(2):315-318.
Manion M, Dimitrova D, Pei L, Gea-Banacloche J, Zelazny A, Lisco A, Zerbe C, Freeman AF, Holland SM, Kanakry CG, Kanakry JA, Sereti I. Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium. Clin Infect Dis. 2020 Feb 3;70(4):676-679.
Manion M, Uldrick T, Polizzotto MN, Sheikh V, Roby G, Lurain K, Metzger D, Mican JM, Pau A, Lisco A, Laidlaw E, Hammoud DA, Whitby D, Yarchoan R, Sereti I. Emergence of Kaposi's Sarcoma Herpesvirus-Associated Complications Following Corticosteroid Use in TB-IRIS. Open Forum Infect Dis. 2018 Oct 12;5(10):ofy217.
Manion M, Hullsiek KH, Wilson EMP, Rhame F, Kojic E, Gibson D, Hammer J, Patel P, Brooks JT, Baker JV, Sereti I; Study to Understand the Natural History of HIV/AIDS in the Era of Effective Antiretroviral Therapy (the ‘SUN Study’) Investigators. Vitamin D deficiency is associated with IL-6 levels and monocyte activation in HIV-infected persons. PLoS One. 2017 May 2;12(5):e0175517.
Manion M, Andrade BB, DerSimonian R, Gu W, Rupert A, Musselwhite LW, Sierra-Madero JG, Belaunzaran-Zamudio PF, Sanne I, Lederman MM, Sereti I. Country of residence is associated with distinct inflammatory biomarker signatures in HIV-infected patients. J Virus Erad. 2017 Jan 1;3(1):24-33. PMID: 28275455; PMCID: PMC5337418.
Dr. Manion performs research in the HIV Pathogenesis Section under the direction of Dr. Irini Sereti where the laboratory's focus is on the inflammatory complications in HIV, particularly looking at immune reconstitution inflammatory syndrome (IRIS) and non-infectious complications like cardiovascular disease.
Dr. Manion’s specific focuses in the laboratory is the characterization of the immune response during IRIS in patients with immunocompromised states other than HIV infection and investigating the consequences and management of inflammation of HIV-1 infection. Dr. Manion is an investigator on a protocol focused on paradoxical reactions in patients with tuberculosis.
Dr. Manion is the government supervisor to the NIAID clinical fellows, and she serves as core faculty for the ACGME accredited fellowship training programs in allergy immunology and infectious diseases.
Manion M, Dulanto Chiang A, Pei L, Wong CS, Khil P, Hammoud DA, Anderson M, Laidlaw E, Kuriakose S, Lisco A; NISC Comparative Sequencing Program, Zelazny AM, Dekker JP, Sereti I. Disseminated Mycobacterium marinum in Human Immunodeficiency Virus Unmasked by Immune Reconstitution Inflammatory Syndrome. J Infect Dis. 2021 Aug 2;224(3):453-457.
Manion M, Lynn N, Pei L, Hammoud DA, Laidlaw E, Roby G, Metzger D, Mejia Y, Lisco A, Zelazny A, Holland S, Vachon ML, Scherer M, Bergin C, Sereti I. To Induce Immune Reconstitution Inflammatory Syndrome or Suppress It: The Spectrum of Mycobacterium genavense in the Antiretroviral Era. Clin Infect Dis. 2021 Jan 27;72(2):315-318.
Manion M, Dimitrova D, Pei L, Gea-Banacloche J, Zelazny A, Lisco A, Zerbe C, Freeman AF, Holland SM, Kanakry CG, Kanakry JA, Sereti I. Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium. Clin Infect Dis. 2020 Feb 3;70(4):676-679.
Manion M, Uldrick T, Polizzotto MN, Sheikh V, Roby G, Lurain K, Metzger D, Mican JM, Pau A, Lisco A, Laidlaw E, Hammoud DA, Whitby D, Yarchoan R, Sereti I. Emergence of Kaposi's Sarcoma Herpesvirus-Associated Complications Following Corticosteroid Use in TB-IRIS. Open Forum Infect Dis. 2018 Oct 12;5(10):ofy217.
Manion M, Hullsiek KH, Wilson EMP, Rhame F, Kojic E, Gibson D, Hammer J, Patel P, Brooks JT, Baker JV, Sereti I; Study to Understand the Natural History of HIV/AIDS in the Era of Effective Antiretroviral Therapy (the ‘SUN Study’) Investigators. Vitamin D deficiency is associated with IL-6 levels and monocyte activation in HIV-infected persons. PLoS One. 2017 May 2;12(5):e0175517.
Manion M, Andrade BB, DerSimonian R, Gu W, Rupert A, Musselwhite LW, Sierra-Madero JG, Belaunzaran-Zamudio PF, Sanne I, Lederman MM, Sereti I. Country of residence is associated with distinct inflammatory biomarker signatures in HIV-infected patients. J Virus Erad. 2017 Jan 1;3(1):24-33. PMID: 28275455; PMCID: PMC5337418.
Principal Investigators: John Chodera, Ph.D.; Benjamin Perry, Ph.D.; Alpha Lee, Ph.D.
Institutes: Sloan Kettering Institute of Cancer Research; Drugs for Neglected Diseases Initiative; PostEra, Inc.
Award #: U19AI171399
The AViDD Centers will conduct innovative, multidisciplinary research to develop candidate COVID-19 antivirals, especially those that can be taken in an outpatient setting, as well as antivirals targeting specific viral families with high potential to cause a pandemic in the future. These include paramyxoviruses, bunyaviruses, togaviruses, filoviruses (including Ebola viruses and Marburg virus), picornaviruses (including enteroviruses and other cold-causing viruses), and flaviviruses (including the viruses that cause yellow fever, dengue and Zika).
The AViDD Centers will conduct research on the early-stage identification and validation of novel viral targets, with an eye to identify small molecules and biotherapeutics that directly block viral targets. As drug candidates are identified and evaluated for properties such as potency and breadth, the most promising will enter late-stage preclinical development. Importantly, the Centers will draw on the resources of their industry partners to accelerate research, making use of the companies’ chemical libraries and expertise in moving candidates into the product development pipeline.
Transmission electron micrograph of SARS-CoV-2 virus particles (yellow) within endosomes of a heavily infected nasal Olfactory Epithelial Cell.