The NIH Center for Human Immunology is an Authorized SomaScan® Assay Provider available to NIH intramural research program investigators.
SomaScan® Assay measures more than 11,000 proteins in only 55 µL of sample. The assay runs on Tecan’s Fluent liquid handling platform and utilizes a unique set of capture reagents called Slow Off-rate Modified Aptamers (SOMAmers®) to measure the relative abundance of proteins in a multitude of biological matrices including human serum, plasma, cerebrospinal fluid, and urine, as well as many others. Through a unique reagent binning design, the assay is capable of spanning 10 logs of dynamic range. The platform is high throughput and is capable of running 81subject samples at a time. In addition, it is highly reproducible, and the median %CV in replicate samples is typically <5%. It has proved widely successful when screening for biomarker signatures in a variety of biomedical applications, such as those predicting patient outcomes or characterizing responses to interventions and therapies. This is typically achieved when utilizing longitudinal samples from individuals, and with study designs including discovery and validation cohorts. Currently, both SomaScan® V4 and V5 are supported at the CHI.
Who Can Use This Resource
This technology is available to NIH intramural researchers through the Center for Human Immunology, Inflammation, and Autoimmunity (CHI) Technical Partnership Program. NIH investigators purchase SomaScan® Assay services at CHI through RTB.NIH.GOV for processing by CHI’s authorized SomaScan® technicians.
How To Access
Requests to utilize the SomaScan® Assay platform can be submitted in the RTB.NIH.GOV system.
For inquiries, contact Brian Sellers.
Location
The SomaScan® Assay is performed on SomaLogic’s automated, high-throughput instrument that is located at the Center for Human Immunology, Inflammation, and Autoimmunity located in Building 10 on the Bethesda main campus.
Research Network Affiliation
NIH Center for Human Immunology, Inflammation, and Autoimmunity
The NIH Center for Human Immunology, Inflammation, and Autoimmunity (CHI) is an affiliate of the National Institute of Allergy and Infectious Diseases Research Technologies Branch. CHI staff collaborate with researchers to apply advanced technologies to achieve an integrated and predictive understanding of human immunity, immune-microbiome behavior and their function in health and disease.
For inquiries about the Center for Human Immunology, Inflammation, and Autoimmunity contact:
Rachel Tracy
Executive Assistant